| 2026-05-23 | St. Louis CityvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2026-05-17 | DC UnitedvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-05-14 | St. Louis CityvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2026-05-10 | Colorado RapidsvSt. Louis CityMLS · United States | 0–1 | MLS · United States |
| 2026-05-03 | Austin FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-04-26 | St. Louis CityvSan Jose EarthquakesMLS · United States | 2–3 | MLS · United States |
| 2026-04-19 | Seattle SoundersvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2026-04-12 | FC DallasvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-04-05 | New York CityvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-03-22 | St. Louis CityvNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2026-03-15 | Los Angeles FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-03-08 | St. Louis CityvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2026-03-02 | San Diego FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-02-21 | St. Louis CityvCharlotteMLS · United States | 1–1 | MLS · United States |
| 2025-10-19 | St. Louis CityvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2025-10-05 | Austin FCvSt. Louis CityMLS · United States | 1–3 | MLS · United States |
| 2025-09-28 | St. Louis CityvLos Angeles FCMLS · United States | 0–3 | MLS · United States |
| 2025-09-21 | San Jose EarthquakesvSt. Louis CityMLS · United States | 1–3 | MLS · United States |
| 2025-09-14 | CF MontrealvSt. Louis CityMLS · United States | 0–2 | MLS · United States |
| 2025-09-07 | St. Louis CityvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2025-08-31 | St. Louis CityvHouston DynamoMLS · United States | 2–3 | MLS · United States |
| 2025-08-24 | Vancouver WhitecapsvSt. Louis CityMLS · United States | 3–2 | MLS · United States |
| 2025-08-17 | Chicago FirevSt. Louis CityMLS · United States | 3–2 | MLS · United States |
| 2025-08-10 | St. Louis CityvNashville SCMLS · United States | 3–1 | MLS · United States |
| 2025-07-27 | St. Louis CityvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2025-07-20 | FC DallasvSt. Louis CityMLS · United States | 3–0 | MLS · United States |
| 2025-07-14 | St. Louis CityvPortland TimbersMLS · United States | 2–1 | MLS · United States |
| 2025-07-06 | Real Salt LakevSt. Louis CityMLS · United States | 3–2 | MLS · United States |
| 2025-06-29 | Houston DynamovSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2025-06-26 | St. Louis CityvOrlando CityMLS · United States | 2–4 | MLS · United States |
| 2025-06-14 | St. Louis CityvLos Angeles GalaxyMLS · United States | 3–3 | MLS · United States |
| 2025-06-09 | Portland TimbersvSt. Louis CityMLS · United States | 2–1 | MLS · United States |
| 2025-05-31 | St. Louis CityvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2025-05-25 | Colorado RapidsvSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2025-05-18 | Minnesota UnitedvSt. Louis CityMLS · United States | 3–0 | MLS · United States |
| 2025-05-15 | St. Louis CityvSporting Kansas CityMLS · United States | 2–2 | MLS · United States |
| 2025-05-11 | St. Louis CityvSan Diego FCMLS · United States | 1–2 | MLS · United States |
| 2025-05-04 | Seattle SoundersvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2025-04-28 | Los Angeles FCvSt. Louis CityMLS · United States | 2–2 | MLS · United States |
| 2025-04-20 | St. Louis CityvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2025-04-14 | St. Louis CityvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2025-04-06 | Sporting Kansas CityvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2025-03-30 | St. Louis CityvAustin FCMLS · United States | 0–1 | MLS · United States |
| 2025-03-22 | Philadelphia UnionvSt. Louis CityMLS · United States | 1–0 | MLS · United States |
| 2025-03-16 | St. Louis CityvSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2025-03-09 | Los Angeles GalaxyvSt. Louis CityMLS · United States | 0–3 | MLS · United States |
| 2025-03-02 | San Diego FCvSt. Louis CityMLS · United States | 0–0 | MLS · United States |
| 2025-02-23 | St. Louis CityvColorado RapidsMLS · United States | 0–0 | MLS · United States |
| 2024-10-20 | Minnesota UnitedvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2024-10-06 | St. Louis CityvHouston DynamoMLS · United States | 3–0 | MLS · United States |