| 2026-05-24 | San Diego FCvVancouver WhitecapsMLS · United States | 2–4 | MLS · United States |
| 2026-05-17 | San Diego FCvFC CincinnatiMLS · United States | 3–3 | MLS · United States |
| 2026-05-14 | San Diego FCvAustin FCMLS · United States | 5–0 | MLS · United States |
| 2026-05-10 | Seattle SoundersvSan Diego FCMLS · United States | 1–1 | MLS · United States |
| 2026-05-03 | San Diego FCvLos Angeles FCMLS · United States | 2–2 | MLS · United States |
| 2026-04-26 | San Diego FCvPortland TimbersMLS · United States | 1–2 | MLS · United States |
| 2026-04-23 | Houston DynamovSan Diego FCMLS · United States | 1–0 | MLS · United States |
| 2026-04-19 | Real Salt LakevSan Diego FCMLS · United States | 4–2 | MLS · United States |
| 2026-04-12 | San Diego FCvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2026-04-05 | San Jose EarthquakesvSan Diego FCMLS · United States | 3–0 | MLS · United States |
| 2026-03-22 | San Diego FCvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2026-03-15 | FC DallasvSan Diego FCMLS · United States | 3–3 | MLS · United States |
| 2026-03-08 | Sporting Kansas CityvSan Diego FCMLS · United States | 0–1 | MLS · United States |
| 2026-03-02 | San Diego FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-02-22 | San Diego FCvCF MontrealMLS · United States | 5–0 | MLS · United States |
| 2025-11-30 | San Diego FCvVancouver WhitecapsMLS · United States | 1–3 | MLS · United States |
| 2025-11-25 | San Diego FCvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2025-11-10 | San Diego FCvPortland TimbersMLS · United States | 4–0 | MLS · United States |
| 2025-11-02 | Portland TimbersvSan Diego FCMLS · United States | 2–2 | MLS · United States |
| 2025-10-27 | San Diego FCvPortland TimbersMLS · United States | 2–1 | MLS · United States |
| 2025-10-19 | Portland TimbersvSan Diego FCMLS · United States | 0–4 | MLS · United States |
| 2025-10-05 | Houston DynamovSan Diego FCMLS · United States | 2–4 | MLS · United States |
| 2025-09-28 | San Diego FCvSan Jose EarthquakesMLS · United States | 0–1 | MLS · United States |
| 2025-09-20 | Atlanta UtdvSan Diego FCMLS · United States | 1–1 | MLS · United States |
| 2025-09-14 | San Diego FCvMinnesota UnitedMLS · United States | 1–3 | MLS · United States |
| 2025-09-01 | Los Angeles FCvSan Diego FCMLS · United States | 1–2 | MLS · United States |
| 2025-08-24 | San Diego FCvPortland TimbersMLS · United States | 0–0 | MLS · United States |
| 2025-08-18 | San Jose EarthquakesvSan Diego FCMLS · United States | 1–2 | MLS · United States |
| 2025-08-10 | Sporting Kansas CityvSan Diego FCMLS · United States | 0–2 | MLS · United States |
| 2025-07-26 | San Diego FCvNashville SCMLS · United States | 1–0 | MLS · United States |
| 2025-07-20 | San Diego FCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2025-07-17 | San Diego FCvToronto FCMLS · United States | 0–1 | MLS · United States |
| 2025-07-13 | Chicago FirevSan Diego FCMLS · United States | 1–2 | MLS · United States |
| 2025-07-06 | San Diego FCvHouston DynamoMLS · United States | 3–4 | MLS · United States |
| 2025-06-29 | FC DallasvSan Diego FCMLS · United States | 2–3 | MLS · United States |
| 2025-06-26 | Vancouver WhitecapsvSan Diego FCMLS · United States | 3–5 | MLS · United States |
| 2025-06-15 | Minnesota UnitedvSan Diego FCMLS · United States | 2–4 | MLS · United States |
| 2025-06-01 | San Diego FCvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2025-05-29 | Seattle SoundersvSan Diego FCMLS · United States | 1–0 | MLS · United States |
| 2025-05-24 | San Diego FCvLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2025-05-18 | San Diego FCvSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2025-05-15 | San Diego FCvColorado RapidsMLS · United States | 2–0 | MLS · United States |
| 2025-05-11 | St. Louis CityvSan Diego FCMLS · United States | 1–2 | MLS · United States |
| 2025-05-04 | San Diego FCvFC DallasMLS · United States | 5–0 | MLS · United States |
| 2025-04-27 | San Diego FCvReal Salt LakeMLS · United States | 1–3 | MLS · United States |
| 2025-04-20 | CharlottevSan Diego FCMLS · United States | 3–0 | MLS · United States |
| 2025-04-13 | Colorado RapidsvSan Diego FCMLS · United States | 3–2 | MLS · United States |
| 2025-04-06 | San Diego FCvSeattle SoundersMLS · United States | 3–0 | MLS · United States |
| 2025-03-30 | San Diego FCvLos Angeles FCMLS · United States | 3–2 | MLS · United States |
| 2025-03-23 | Austin FCvSan Diego FCMLS · United States | 2–1 | MLS · United States |