| 2025-03-02 | New England RevolutionvColumbus CrewMLS · United States | 0–1 | MLS · United States |
| 2025-02-23 | Columbus CrewvChicago FireMLS · United States | 4–2 | MLS · United States |
| 2024-11-03 | New York Red BullsvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2024-10-29 | Columbus CrewvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2024-10-19 | New York Red BullsvColumbus CrewMLS · United States | 2–3 | MLS · United States |
| 2024-10-13 | Columbus CrewvNew England RevolutionMLS · United States | 4–0 | MLS · United States |
| 2024-10-06 | Columbus CrewvPhiladelphia UnionMLS · United States | 3–2 | MLS · United States |
| 2024-10-03 | Columbus CrewvInter MiamiMLS · United States | 2–3 | MLS · United States |
| 2024-09-29 | DC UnitedvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2024-09-22 | Columbus CrewvOrlando CityMLS · United States | 4–3 | MLS · United States |
| 2024-09-19 | Toronto FCvColumbus CrewMLS · United States | 0–2 | MLS · United States |
| 2024-09-15 | FC CincinnativColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2024-09-08 | Columbus CrewvSeattle SoundersMLS · United States | 0–4 | MLS · United States |
| 2024-09-01 | Columbus CrewvNew York CityMLS · United States | 4–2 | MLS · United States |
| 2024-08-29 | Philadelphia UnionvColumbus CrewMLS · United States | 0–1 | MLS · United States |
| 2024-07-21 | Atlanta UtdvColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2024-07-18 | Columbus CrewvCharlotteMLS · United States | 1–1 | MLS · United States |
| 2024-07-14 | Los Angeles FCvColumbus CrewMLS · United States | 1–5 | MLS · United States |
| 2024-07-07 | Columbus CrewvToronto FCMLS · United States | 4–0 | MLS · United States |
| 2024-07-03 | Columbus CrewvNashville SCMLS · United States | 2–0 | MLS · United States |
| 2024-06-30 | New England RevolutionvColumbus CrewMLS · United States | 1–5 | MLS · United States |
| 2024-06-23 | Columbus CrewvSporting Kansas CityMLS · United States | 4–0 | MLS · United States |
| 2024-06-20 | Inter MiamivColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2024-06-15 | New York CityvColumbus CrewMLS · United States | 2–3 | MLS · United States |
| 2024-05-26 | Orlando CityvColumbus CrewMLS · United States | 0–2 | MLS · United States |
| 2024-05-19 | Chicago FirevColumbus CrewMLS · United States | 1–3 | MLS · United States |
| 2024-05-16 | CF MontrealvColumbus CrewMLS · United States | 1–3 | MLS · United States |
| 2024-05-12 | Columbus CrewvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2024-04-28 | Columbus CrewvCF MontrealMLS · United States | 0–0 | MLS · United States |
| 2024-04-21 | Columbus CrewvPortland TimbersMLS · United States | 2–2 | MLS · United States |
| 2024-04-14 | Real Salt LakevColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2024-04-07 | Columbus CrewvDC UnitedMLS · United States | 1–1 | MLS · United States |
| 2024-03-31 | Nashville SCvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2024-03-23 | CharlottevColumbus CrewMLS · United States | 2–0 | MLS · United States |
| 2024-03-16 | Columbus CrewvNew York Red BullsMLS · United States | 3–0 | MLS · United States |
| 2024-03-10 | Columbus CrewvChicago FireMLS · United States | 2–1 | MLS · United States |
| 2024-03-02 | Minnesota UnitedvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2024-02-24 | Columbus CrewvAtlanta UtdMLS · United States | 1–0 | MLS · United States |
| 2023-12-09 | Columbus CrewvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2023-12-02 | FC CincinnativColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2023-11-25 | Orlando CityvColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2023-11-13 | Columbus CrewvAtlanta UtdMLS · United States | 4–2 | MLS · United States |
| 2023-11-08 | Atlanta UtdvColumbus CrewMLS · United States | 4–2 | MLS · United States |
| 2023-11-01 | Columbus CrewvAtlanta UtdMLS · United States | 2–0 | MLS · United States |
| 2023-10-21 | Columbus CrewvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2023-10-08 | Atlanta UtdvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2023-10-05 | New England RevolutionvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2023-10-01 | Columbus CrewvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2023-09-24 | FC DallasvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2023-09-21 | Columbus CrewvChicago FireMLS · United States | 3–0 | MLS · United States |