| 2021-09-26 | SouthamptonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-09-18 | Man CityvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2021-09-11 | SouthamptonvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-08-28 | NewcastlevSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2021-08-22 | SouthamptonvMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-08-14 | EvertonvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2021-05-23 | West HamvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-05-18 | SouthamptonvLeedsPremier League · England | 0–2 | Premier League · England |
| 2021-05-15 | SouthamptonvFulhamPremier League · England | 3–1 | Premier League · England |
| 2021-05-11 | SouthamptonvCrystal PalacePremier League · England | 3–1 | Premier League · England |
| 2021-05-08 | LiverpoolvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2021-04-30 | SouthamptonvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2021-04-21 | TottenhamvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2021-04-12 | West BromvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-04-04 | SouthamptonvBurnleyPremier League · England | 3–2 | Premier League · England |
| 2021-03-14 | SouthamptonvBrightonPremier League · England | 1–2 | Premier League · England |
| 2021-03-10 | Man CityvSouthamptonPremier League · England | 5–2 | Premier League · England |
| 2021-03-06 | Sheffield UnitedvSouthamptonPremier League · England | 0–2 | Premier League · England |
| 2021-03-01 | EvertonvSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2021-02-23 | LeedsvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-02-20 | SouthamptonvChelseaPremier League · England | 1–1 | Premier League · England |
| 2021-02-14 | SouthamptonvWolvesPremier League · England | 1–2 | Premier League · England |
| 2021-02-06 | NewcastlevSouthamptonPremier League · England | 3–2 | Premier League · England |
| 2021-02-02 | Man UnitedvSouthamptonPremier League · England | 9–0 | Premier League · England |
| 2021-01-30 | SouthamptonvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-01-26 | SouthamptonvArsenalPremier League · England | 1–3 | Premier League · England |
| 2021-01-16 | LeicestervSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2021-01-04 | SouthamptonvLiverpoolPremier League · England | 1–0 | Premier League · England |
| 2020-12-29 | SouthamptonvWest HamPremier League · England | 0–0 | Premier League · England |
| 2020-12-26 | FulhamvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2020-12-19 | SouthamptonvMan CityPremier League · England | 0–1 | Premier League · England |
| 2020-12-16 | ArsenalvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2020-12-13 | SouthamptonvSheffield UnitedPremier League · England | 3–0 | Premier League · England |
| 2020-12-07 | BrightonvSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2020-11-29 | SouthamptonvMan UnitedPremier League · England | 2–3 | Premier League · England |
| 2020-11-23 | WolvesvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2020-11-06 | SouthamptonvNewcastlePremier League · England | 2–0 | Premier League · England |
| 2020-11-01 | Aston VillavSouthamptonPremier League · England | 3–4 | Premier League · England |
| 2020-10-25 | SouthamptonvEvertonPremier League · England | 2–0 | Premier League · England |
| 2020-10-17 | ChelseavSouthamptonPremier League · England | 3–3 | Premier League · England |
| 2020-10-04 | SouthamptonvWest BromPremier League · England | 2–0 | Premier League · England |
| 2020-09-26 | BurnleyvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2020-09-20 | SouthamptonvTottenhamPremier League · England | 2–5 | Premier League · England |
| 2020-09-12 | Crystal PalacevSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2020-07-26 | SouthamptonvSheffield UnitedPremier League · England | 3–1 | Premier League · England |
| 2020-07-19 | BournemouthvSouthamptonPremier League · England | 0–2 | Premier League · England |
| 2020-07-16 | SouthamptonvBrightonPremier League · England | 1–1 | Premier League · England |
| 2020-07-13 | Man UnitedvSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2020-07-09 | EvertonvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2020-07-05 | SouthamptonvMan CityPremier League · England | 1–0 | Premier League · England |