| 2025-04-26 | SouthamptonvFulhamPremier League · England | 1–2 | Premier League · England |
| 2025-04-19 | West HamvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2025-04-12 | SouthamptonvAston VillaPremier League · England | 0–3 | Premier League · England |
| 2025-04-06 | TottenhamvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2025-04-02 | SouthamptonvCrystal PalacePremier League · England | 1–1 | Premier League · England |
| 2025-03-15 | SouthamptonvWolvesPremier League · England | 1–2 | Premier League · England |
| 2025-03-08 | LiverpoolvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2025-02-25 | ChelseavSouthamptonPremier League · England | 4–0 | Premier League · England |
| 2025-02-22 | SouthamptonvBrightonPremier League · England | 0–4 | Premier League · England |
| 2025-02-15 | SouthamptonvBournemouthPremier League · England | 1–3 | Premier League · England |
| 2025-02-01 | IpswichvSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2025-01-25 | SouthamptonvNewcastlePremier League · England | 1–3 | Premier League · England |
| 2025-01-19 | Nott'm ForestvSouthamptonPremier League · England | 3–2 | Premier League · England |
| 2025-01-16 | Man UnitedvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2025-01-04 | SouthamptonvBrentfordPremier League · England | 0–5 | Premier League · England |
| 2024-12-29 | Crystal PalacevSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2024-12-26 | SouthamptonvWest HamPremier League · England | 0–1 | Premier League · England |
| 2024-12-22 | FulhamvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2024-12-15 | SouthamptonvTottenhamPremier League · England | 0–5 | Premier League · England |
| 2024-12-07 | Aston VillavSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2024-12-04 | SouthamptonvChelseaPremier League · England | 1–5 | Premier League · England |
| 2024-11-29 | BrightonvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2024-11-24 | SouthamptonvLiverpoolPremier League · England | 2–3 | Premier League · England |
| 2024-11-09 | WolvesvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2024-11-02 | SouthamptonvEvertonPremier League · England | 1–0 | Premier League · England |
| 2024-10-26 | Man CityvSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2024-10-19 | SouthamptonvLeicesterPremier League · England | 2–3 | Premier League · England |
| 2024-10-05 | ArsenalvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2024-09-30 | BournemouthvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2024-09-21 | SouthamptonvIpswichPremier League · England | 1–1 | Premier League · England |
| 2024-09-14 | SouthamptonvMan UnitedPremier League · England | 0–3 | Premier League · England |
| 2024-08-31 | BrentfordvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2024-08-24 | SouthamptonvNott'm ForestPremier League · England | 0–1 | Premier League · England |
| 2024-08-17 | NewcastlevSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2024-05-04 | LeedsvSouthamptonChampionship · England | 1–2 | Championship · England |
| 2024-04-27 | SouthamptonvStokeChampionship · England | 0–1 | Championship · England |
| 2024-04-23 | LeicestervSouthamptonChampionship · England | 5–0 | Championship · England |
| 2024-04-20 | CardiffvSouthamptonChampionship · England | 2–1 | Championship · England |
| 2024-04-16 | SouthamptonvPrestonChampionship · England | 3–0 | Championship · England |
| 2024-04-13 | SouthamptonvWatfordChampionship · England | 3–2 | Championship · England |
| 2024-04-09 | SouthamptonvCoventryChampionship · England | 2–1 | Championship · England |
| 2024-04-06 | BlackburnvSouthamptonChampionship · England | 0–0 | Championship · England |
| 2024-04-01 | IpswichvSouthamptonChampionship · England | 3–2 | Championship · England |
| 2024-03-29 | SouthamptonvMiddlesbroughChampionship · England | 1–1 | Championship · England |
| 2024-03-09 | SouthamptonvSunderlandChampionship · England | 4–2 | Championship · England |
| 2024-03-02 | BirminghamvSouthamptonChampionship · England | 3–4 | Championship · England |
| 2024-02-24 | SouthamptonvMillwallChampionship · England | 1–2 | Championship · England |
| 2024-02-20 | SouthamptonvHullChampionship · England | 1–2 | Championship · England |
| 2024-02-16 | West BromvSouthamptonChampionship · England | 0–2 | Championship · England |
| 2024-02-13 | Bristol CityvSouthamptonChampionship · England | 3–1 | Championship · England |