| 2021-12-28 | WatfordvWest HamPremier League · England | 1–4 | Premier League · England |
| 2021-12-26 | West HamvSouthamptonPremier League · England | 2–3 | Premier League · England |
| 2021-12-15 | ArsenalvWest HamPremier League · England | 2–0 | Premier League · England |
| 2021-12-12 | BurnleyvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-12-04 | West HamvChelseaPremier League · England | 3–2 | Premier League · England |
| 2021-12-01 | West HamvBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-11-28 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-11-20 | WolvesvWest HamPremier League · England | 1–0 | Premier League · England |
| 2021-11-07 | West HamvLiverpoolPremier League · England | 3–2 | Premier League · England |
| 2021-10-31 | Aston VillavWest HamPremier League · England | 1–4 | Premier League · England |
| 2021-10-24 | West HamvTottenhamPremier League · England | 1–0 | Premier League · England |
| 2021-10-17 | EvertonvWest HamPremier League · England | 0–1 | Premier League · England |
| 2021-10-03 | West HamvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2021-09-25 | LeedsvWest HamPremier League · England | 1–2 | Premier League · England |
| 2021-09-19 | West HamvMan UnitedPremier League · England | 1–2 | Premier League · England |
| 2021-09-11 | SouthamptonvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-08-28 | West HamvCrystal PalacePremier League · England | 2–2 | Premier League · England |
| 2021-08-23 | West HamvLeicesterPremier League · England | 4–1 | Premier League · England |
| 2021-08-15 | NewcastlevWest HamPremier League · England | 2–4 | Premier League · England |
| 2021-05-23 | West HamvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-05-19 | West BromvWest HamPremier League · England | 1–3 | Premier League · England |
| 2021-05-15 | BrightonvWest HamPremier League · England | 1–1 | Premier League · England |
| 2021-05-09 | West HamvEvertonPremier League · England | 0–1 | Premier League · England |
| 2021-05-03 | BurnleyvWest HamPremier League · England | 1–2 | Premier League · England |
| 2021-04-24 | West HamvChelseaPremier League · England | 0–1 | Premier League · England |
| 2021-04-17 | NewcastlevWest HamPremier League · England | 3–2 | Premier League · England |
| 2021-04-11 | West HamvLeicesterPremier League · England | 3–2 | Premier League · England |
| 2021-04-05 | WolvesvWest HamPremier League · England | 2–3 | Premier League · England |
| 2021-03-21 | West HamvArsenalPremier League · England | 3–3 | Premier League · England |
| 2021-03-14 | Man UnitedvWest HamPremier League · England | 1–0 | Premier League · England |
| 2021-03-08 | West HamvLeedsPremier League · England | 2–0 | Premier League · England |
| 2021-02-27 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-02-21 | West HamvTottenhamPremier League · England | 2–1 | Premier League · England |
| 2021-02-15 | West HamvSheffield UnitedPremier League · England | 3–0 | Premier League · England |
| 2021-02-06 | FulhamvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-02-03 | Aston VillavWest HamPremier League · England | 1–3 | Premier League · England |
| 2021-01-31 | West HamvLiverpoolPremier League · England | 1–3 | Premier League · England |
| 2021-01-26 | Crystal PalacevWest HamPremier League · England | 2–3 | Premier League · England |
| 2021-01-19 | West HamvWest BromPremier League · England | 2–1 | Premier League · England |
| 2021-01-16 | West HamvBurnleyPremier League · England | 1–0 | Premier League · England |
| 2021-01-01 | EvertonvWest HamPremier League · England | 0–1 | Premier League · England |