| 2025-12-06 | Inter MiamivVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2025-11-30 | San Diego FCvVancouver WhitecapsMLS · United States | 1–3 | MLS · United States |
| 2025-11-23 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 2–2 | MLS · United States |
| 2025-11-02 | FC DallasvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2025-10-26 | Vancouver WhitecapsvFC DallasMLS · United States | 3–0 | MLS · United States |
| 2025-10-19 | Vancouver WhitecapsvFC DallasMLS · United States | 1–2 | MLS · United States |
| 2025-10-12 | Orlando CityvVancouver WhitecapsMLS · United States | 1–2 | MLS · United States |
| 2025-10-05 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 4–1 | MLS · United States |
| 2025-09-28 | Seattle SoundersvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2025-09-25 | Vancouver WhitecapsvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2025-09-21 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 0–2 | MLS · United States |
| 2025-09-14 | Vancouver WhitecapsvPhiladelphia UnionMLS · United States | 7–0 | MLS · United States |
| 2025-08-24 | Vancouver WhitecapsvSt. Louis CityMLS · United States | 3–2 | MLS · United States |
| 2025-08-18 | Vancouver WhitecapsvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2025-08-10 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2025-07-27 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 3–0 | MLS · United States |
| 2025-07-20 | San Diego FCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2025-07-17 | Houston DynamovVancouver WhitecapsMLS · United States | 0–3 | MLS · United States |
| 2025-07-13 | Colorado RapidsvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2025-07-05 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2025-06-30 | Los Angeles FCvVancouver WhitecapsMLS · United States | 0–1 | MLS · United States |
| 2025-06-26 | Vancouver WhitecapsvSan Diego FCMLS · United States | 3–5 | MLS · United States |
| 2025-06-15 | Columbus CrewvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2025-06-09 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 3–0 | MLS · United States |
| 2025-05-29 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 0–0 | MLS · United States |
| 2025-05-25 | Real Salt LakevVancouver WhitecapsMLS · United States | 2–3 | MLS · United States |
| 2025-05-18 | Austin FCvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2025-05-12 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 2–2 | MLS · United States |
| 2025-05-04 | Vancouver WhitecapsvReal Salt LakeMLS · United States | 2–1 | MLS · United States |
| 2025-04-27 | Minnesota UnitedvVancouver WhitecapsMLS · United States | 1–3 | MLS · United States |
| 2025-04-20 | St. Louis CityvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2025-04-13 | Vancouver WhitecapsvAustin FCMLS · United States | 5–1 | MLS · United States |
| 2025-04-06 | Vancouver WhitecapsvColorado RapidsMLS · United States | 2–0 | MLS · United States |
| 2025-03-29 | Toronto FCvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2025-03-23 | Vancouver WhitecapsvChicago FireMLS · United States | 1–3 | MLS · United States |
| 2025-03-16 | FC DallasvVancouver WhitecapsMLS · United States | 0–1 | MLS · United States |
| 2025-03-09 | Vancouver WhitecapsvCF MontrealMLS · United States | 2–0 | MLS · United States |
| 2025-03-02 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2025-02-23 | Portland TimbersvVancouver WhitecapsMLS · United States | 1–4 | MLS · United States |