| 2022-10-09 | Minnesota UnitedvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2022-10-02 | Vancouver WhitecapsvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2022-09-18 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2022-09-15 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 3–0 | MLS · United States |
| 2022-09-11 | Colorado RapidsvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-09-05 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2022-08-28 | Vancouver WhitecapsvNashville SCMLS · United States | 0–3 | MLS · United States |
| 2022-08-21 | Real Salt LakevVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2022-08-18 | Vancouver WhitecapsvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2022-08-14 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 5–2 | MLS · United States |
| 2022-08-06 | Vancouver WhitecapsvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-07-31 | Nashville SCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2022-07-24 | Vancouver WhitecapsvChicago FireMLS · United States | 1–3 | MLS · United States |
| 2022-07-18 | Portland TimbersvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2022-07-14 | FC CincinnativVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2022-07-09 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 1–3 | MLS · United States |
| 2022-07-03 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 1–0 | MLS · United States |
| 2022-06-27 | Vancouver WhitecapsvNew England RevolutionMLS · United States | 0–0 | MLS · United States |
| 2022-06-19 | FC DallasvVancouver WhitecapsMLS · United States | 0–2 | MLS · United States |
| 2022-06-15 | Seattle SoundersvVancouver WhitecapsMLS · United States | 4–0 | MLS · United States |
| 2022-06-05 | Vancouver WhitecapsvReal Salt LakeMLS · United States | 2–1 | MLS · United States |
| 2022-05-29 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 0–1 | MLS · United States |
| 2022-05-22 | CharlottevVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-05-19 | Vancouver WhitecapsvFC DallasMLS · United States | 2–1 | MLS · United States |
| 2022-05-15 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 3–3 | MLS · United States |
| 2022-05-08 | Vancouver WhitecapsvToronto FCMLS · United States | 1–0 | MLS · United States |
| 2022-04-24 | Austin FCvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2022-04-16 | CF MontrealvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-04-10 | Vancouver WhitecapsvPortland TimbersMLS · United States | 2–3 | MLS · United States |
| 2022-04-03 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 1–0 | MLS · United States |
| 2022-03-21 | Los Angeles FCvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2022-03-12 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-03-05 | Vancouver WhitecapsvNew York CityMLS · United States | 0–0 | MLS · United States |
| 2022-02-26 | Columbus CrewvVancouver WhitecapsMLS · United States | 4–0 | MLS · United States |