| 2021-11-20 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2021-11-07 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2021-11-03 | Los Angeles FCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-10-28 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 2–1 | MLS · United States |
| 2021-10-24 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-10-21 | Portland TimbersvVancouver WhitecapsMLS · United States | 2–3 | MLS · United States |
| 2021-10-18 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 2–1 | MLS · United States |
| 2021-10-10 | Seattle SoundersvVancouver WhitecapsMLS · United States | 4–1 | MLS · United States |
| 2021-10-03 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2021-09-30 | Houston DynamovVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-09-26 | Vancouver WhitecapsvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2021-09-20 | Colorado RapidsvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-09-11 | Vancouver WhitecapsvPortland TimbersMLS · United States | 0–1 | MLS · United States |
| 2021-09-05 | Vancouver WhitecapsvAustin FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-30 | Vancouver WhitecapsvReal Salt LakeMLS · United States | 4–1 | MLS · United States |
| 2021-08-22 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-19 | Austin FCvVancouver WhitecapsMLS · United States | 1–2 | MLS · United States |
| 2021-08-14 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-08-09 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-08-01 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 2–2 | MLS · United States |
| 2021-07-25 | Los Angeles FCvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2021-07-21 | Vancouver WhitecapsvHouston DynamoMLS · United States | 0–0 | MLS · United States |
| 2021-07-18 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2021-07-08 | Vancouver WhitecapsvReal Salt LakeMLS · United States | 0–4 | MLS · United States |
| 2021-07-05 | FC DallasvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2021-06-27 | Seattle SoundersvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2021-06-24 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 1–2 | MLS · United States |
| 2021-06-19 | Real Salt LakevVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2021-05-23 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2021-05-16 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2021-05-13 | Minnesota UnitedvVancouver WhitecapsMLS · United States | 1–0 | MLS · United States |
| 2021-05-08 | Vancouver WhitecapsvCF MontrealMLS · United States | 2–0 | MLS · United States |
| 2021-05-03 | Vancouver WhitecapsvColorado RapidsMLS · United States | 0–1 | MLS · United States |
| 2021-04-24 | Toronto FCvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2021-04-19 | Vancouver WhitecapsvPortland TimbersMLS · United States | 1–0 | MLS · United States |