| 2026-09-13 | St. Louis CityvMinnesota UnitedMLS · United States | 4–2 | MLS · United States |
| 2026-09-10 | Portland TimbersvSt. Louis CityMLS · United States | 2–2 | MLS · United States |
| 2026-09-06 | Vancouver WhitecapsvSt. Louis CityMLS · United States | 1–3 | MLS · United States |
| 2026-08-31 | St. Louis CityvFC DallasMLS · United States | 3–3 | MLS · United States |
| 2026-08-23 | St. Louis CityvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2026-08-20 | Sporting Kansas CityvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-08-16 | San Jose EarthquakesvSt. Louis CityMLS · United States | 1–3 | MLS · United States |
| 2026-08-02 | St. Louis CityvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2026-07-26 | St. Louis CityvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2026-07-23 | Los Angeles GalaxyvSt. Louis CityMLS · United States | 1–3 | MLS · United States |
| 2026-07-17 | St. Louis CityvSporting Kansas CityMLS · United States | 3–2 | MLS · United States |
| 2026-05-23 | St. Louis CityvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2026-05-17 | DC UnitedvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-05-14 | St. Louis CityvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2026-05-10 | Colorado RapidsvSt. Louis CityMLS · United States | 0–1 | MLS · United States |
| 2026-05-03 | Austin FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-04-26 | St. Louis CityvSan Jose EarthquakesMLS · United States | 2–3 | MLS · United States |
| 2026-04-19 | Seattle SoundersvSt. Louis CityMLS · United States | 4–1 | MLS · United States |
| 2026-04-12 | FC DallasvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-04-05 | New York CityvSt. Louis CityMLS · United States | 1–1 | MLS · United States |
| 2026-03-22 | St. Louis CityvNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2026-03-15 | Los Angeles FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-03-08 | St. Louis CityvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2026-03-02 | San Diego FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-02-21 | St. Louis CityvCharlotteMLS · United States | 1–1 | MLS · United States |