| 2005-12-26 | SouthportvMorecambeNational League · England | 0–3 | National League · England |
| 2005-12-10 | AldershotvSouthportNational League · England | 2–0 | National League · England |
| 2005-11-26 | AccringtonvSouthportNational League · England | 4–0 | National League · England |
| 2005-11-19 | SouthportvHalifaxNational League · England | 0–2 | National League · England |
| 2005-11-12 | Crawley TownvSouthportNational League · England | 2–0 | National League · England |
| 2005-10-29 | SouthportvGraysNational League · England | 1–4 | National League · England |
| 2005-10-15 | AltrinchamvSouthportNational League · England | 1–0 | National League · England |
| 2005-10-07 | SouthportvForest GreenNational League · England | 3–1 | National League · England |
| 2005-10-01 | SouthportvCambridgeNational League · England | 2–2 | National League · England |
| 2005-09-27 | ScarboroughvSouthportNational League · England | 0–1 | National League · England |
| 2005-09-24 | Canvey IslandvSouthportNational League · England | 2–1 | National League · England |
| 2005-09-20 | SouthportvTamworthNational League · England | 1–1 | National League · England |
| 2005-09-17 | SouthportvExeterNational League · England | 0–3 | National League · England |
| 2005-09-10 | WokingvSouthportNational League · England | 1–0 | National League · England |
| 2005-09-03 | GravesendvSouthportNational League · England | 2–1 | National League · England |
| 2005-08-29 | SouthportvBurtonNational League · England | 3–2 | National League · England |
| 2005-08-27 | KidderminstervSouthportNational League · England | 1–1 | National League · England |
| 2005-08-20 | SouthportvStevenageNational League · England | 3–2 | National League · England |
| 2005-08-16 | SouthportvYorkNational League · England | 1–4 | National League · England |
| 2005-08-13 | Dag and RedvSouthportNational League · England | 3–1 | National League · England |