| 2010-12-14 | CheltenhamvSouthendLeague Two · England | 0–2 | League Two · England |
| 2010-12-11 | BurtonvSouthendLeague Two · England | 3–1 | League Two · England |
| 2010-11-23 | StevenagevSouthendLeague Two · England | 1–1 | League Two · England |
| 2010-11-20 | ShrewsburyvSouthendLeague Two · England | 1–1 | League Two · England |
| 2010-11-13 | SouthendvAccringtonLeague Two · England | 1–1 | League Two · England |
| 2010-10-30 | SouthendvRotherhamLeague Two · England | 1–0 | League Two · England |
| 2010-10-23 | BuryvSouthendLeague Two · England | 1–0 | League Two · England |
| 2010-10-16 | SouthendvCreweLeague Two · England | 0–2 | League Two · England |
| 2010-10-09 | ChesterfieldvSouthendLeague Two · England | 2–1 | League Two · England |
| 2010-10-02 | SouthendvLincolnLeague Two · England | 1–0 | League Two · England |
| 2010-09-28 | GillinghamvSouthendLeague Two · England | 0–0 | League Two · England |
| 2010-09-25 | HerefordvSouthendLeague Two · England | 1–3 | League Two · England |
| 2010-09-18 | SouthendvMorecambeLeague Two · England | 2–3 | League Two · England |
| 2010-09-11 | NorthamptonvSouthendLeague Two · England | 2–1 | League Two · England |
| 2010-09-04 | SouthendvTorquayLeague Two · England | 2–1 | League Two · England |
| 2010-08-27 | BradfordvSouthendLeague Two · England | 0–2 | League Two · England |
| 2010-08-21 | SouthendvPort ValeLeague Two · England | 1–3 | League Two · England |
| 2010-08-14 | AldershotvSouthendLeague Two · England | 1–0 | League Two · England |
| 2010-08-07 | SouthendvStockportLeague Two · England | 1–1 | League Two · England |
| 2010-05-08 | SouthamptonvSouthendLeague One · England | 3–1 | League One · England |
| 2010-05-01 | SouthendvStockportLeague One · England | 2–1 | League One · England |
| 2010-04-24 | OldhamvSouthendLeague One · England | 2–2 | League One · England |
| 2010-04-17 | SouthendvBrightonLeague One · England | 0–1 | League One · England |
| 2010-04-13 | SouthendvBrentfordLeague One · England | 2–2 | League One · England |
| 2010-04-10 | LeedsvSouthendLeague One · England | 2–0 | League One · England |
| 2010-04-05 | GillinghamvSouthendLeague One · England | 3–0 | League One · England |
| 2010-04-03 | SouthendvYeovilLeague One · England | 0–0 | League One · England |
| 2010-03-27 | Bristol RvsvSouthendLeague One · England | 4–3 | League One · England |
| 2010-03-23 | SouthendvWalsallLeague One · England | 3–0 | League One · England |
| 2010-03-20 | SouthendvCarlisleLeague One · England | 2–2 | League One · England |
| 2010-03-13 | SouthendvExeterLeague One · England | 0–0 | League One · England |
| 2010-03-06 | HartlepoolvSouthendLeague One · England | 3–0 | League One · England |
| 2010-02-26 | SouthendvCharltonLeague One · England | 1–2 | League One · England |
| 2010-02-23 | NorwichvSouthendLeague One · England | 2–1 | League One · England |
| 2010-02-20 | Milton Keynes DonsvSouthendLeague One · England | 3–1 | League One · England |
| 2010-02-13 | SouthendvTranmereLeague One · England | 1–1 | League One · England |
| 2010-02-08 | ColchestervSouthendLeague One · England | 2–0 | League One · England |
| 2010-01-30 | SouthendvSwindonLeague One · England | 2–2 | League One · England |
| 2010-01-26 | MillwallvSouthendLeague One · England | 2–0 | League One · England |
| 2010-01-23 | SouthendvWycombeLeague One · England | 1–1 | League One · England |
| 2010-01-16 | HuddersfieldvSouthendLeague One · England | 2–1 | League One · England |