| 2022-12-31 | FulhamvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2022-12-26 | SouthamptonvBrightonPremier League · England | 1–3 | Premier League · England |
| 2022-11-12 | LiverpoolvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2022-11-06 | SouthamptonvNewcastlePremier League · England | 1–4 | Premier League · England |
| 2022-10-29 | Crystal PalacevSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2022-10-23 | SouthamptonvArsenalPremier League · England | 1–1 | Premier League · England |
| 2022-10-19 | BournemouthvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2022-10-16 | SouthamptonvWest HamPremier League · England | 1–1 | Premier League · England |
| 2022-10-08 | Man CityvSouthamptonPremier League · England | 4–0 | Premier League · England |
| 2022-10-01 | SouthamptonvEvertonPremier League · England | 1–2 | Premier League · England |
| 2022-09-16 | Aston VillavSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2022-09-03 | WolvesvSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2022-08-30 | SouthamptonvChelseaPremier League · England | 2–1 | Premier League · England |
| 2022-08-27 | SouthamptonvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2022-08-20 | LeicestervSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2022-08-13 | SouthamptonvLeedsPremier League · England | 2–2 | Premier League · England |
| 2022-08-06 | TottenhamvSouthamptonPremier League · England | 4–1 | Premier League · England |
| 2022-05-22 | LeicestervSouthamptonPremier League · England | 4–1 | Premier League · England |
| 2022-05-17 | SouthamptonvLiverpoolPremier League · England | 1–2 | Premier League · England |
| 2022-05-07 | BrentfordvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2022-04-30 | SouthamptonvCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2022-04-24 | BrightonvSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2022-04-21 | BurnleyvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2022-04-16 | SouthamptonvArsenalPremier League · England | 1–0 | Premier League · England |
| 2022-04-09 | SouthamptonvChelseaPremier League · England | 0–6 | Premier League · England |
| 2022-04-02 | LeedsvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2022-03-13 | SouthamptonvWatfordPremier League · England | 1–2 | Premier League · England |
| 2022-03-10 | SouthamptonvNewcastlePremier League · England | 1–2 | Premier League · England |
| 2022-03-05 | Aston VillavSouthamptonPremier League · England | 4–0 | Premier League · England |
| 2022-02-25 | SouthamptonvNorwichPremier League · England | 2–0 | Premier League · England |
| 2022-02-19 | SouthamptonvEvertonPremier League · England | 2–0 | Premier League · England |
| 2022-02-12 | Man UnitedvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2022-02-09 | TottenhamvSouthamptonPremier League · England | 2–3 | Premier League · England |
| 2022-01-22 | SouthamptonvMan CityPremier League · England | 1–1 | Premier League · England |
| 2022-01-15 | WolvesvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2022-01-11 | SouthamptonvBrentfordPremier League · England | 4–1 | Premier League · England |