| 2016-12-31 | SouthamptonvWest BromPremier League · England | 1–2 | Premier League · England |
| 2016-12-28 | SouthamptonvTottenhamPremier League · England | 1–4 | Premier League · England |
| 2016-12-18 | BournemouthvSouthamptonPremier League · England | 1–3 | Premier League · England |
| 2016-12-14 | StokevSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-12-11 | SouthamptonvMiddlesbroughPremier League · England | 1–0 | Premier League · England |
| 2016-12-03 | Crystal PalacevSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2016-11-27 | SouthamptonvEvertonPremier League · England | 1–0 | Premier League · England |
| 2016-11-19 | SouthamptonvLiverpoolPremier League · England | 0–0 | Premier League · England |
| 2016-11-06 | HullvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2016-10-30 | SouthamptonvChelseaPremier League · England | 0–2 | Premier League · England |
| 2016-10-23 | Man CityvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2016-10-16 | SouthamptonvBurnleyPremier League · England | 3–1 | Premier League · England |
| 2016-10-02 | LeicestervSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-09-25 | West HamvSouthamptonPremier League · England | 0–3 | Premier League · England |
| 2016-09-18 | SouthamptonvSwanseaPremier League · England | 1–0 | Premier League · England |
| 2016-09-10 | ArsenalvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2016-08-27 | SouthamptonvSunderlandPremier League · England | 1–1 | Premier League · England |
| 2016-08-19 | Man UnitedvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2016-08-13 | SouthamptonvWatfordPremier League · England | 1–1 | Premier League · England |
| 2016-05-15 | SouthamptonvCrystal PalacePremier League · England | 4–1 | Premier League · England |
| 2016-05-08 | TottenhamvSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2016-05-01 | SouthamptonvMan CityPremier League · England | 4–2 | Premier League · England |
| 2016-04-23 | Aston VillavSouthamptonPremier League · England | 2–4 | Premier League · England |
| 2016-04-16 | EvertonvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2016-04-09 | SouthamptonvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2016-04-03 | LeicestervSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2016-03-20 | SouthamptonvLiverpoolPremier League · England | 3–2 | Premier League · England |
| 2016-03-12 | StokevSouthamptonPremier League · England | 1–2 | Premier League · England |
| 2016-03-05 | SouthamptonvSunderlandPremier League · England | 1–1 | Premier League · England |
| 2016-03-01 | BournemouthvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2016-02-27 | SouthamptonvChelseaPremier League · England | 1–2 | Premier League · England |
| 2016-02-13 | SwanseavSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2016-02-06 | SouthamptonvWest HamPremier League · England | 1–0 | Premier League · England |
| 2016-02-02 | ArsenalvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2016-01-23 | Man UnitedvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2016-01-16 | SouthamptonvWest BromPremier League · England | 3–0 | Premier League · England |
| 2016-01-13 | SouthamptonvWatfordPremier League · England | 2–0 | Premier League · England |
| 2016-01-02 | NorwichvSouthamptonPremier League · England | 1–0 | Premier League · England |