| 2010-12-28 | SouthamptonvHuddersfieldLeague One · England | 4–1 | League One · England |
| 2010-12-11 | SouthamptonvBrentfordLeague One · England | 0–2 | League One · England |
| 2010-11-23 | SouthamptonvBrightonLeague One · England | 0–0 | League One · England |
| 2010-11-20 | SouthamptonvPeterboroLeague One · England | 4–1 | League One · England |
| 2010-11-13 | CarlislevSouthamptonLeague One · England | 3–2 | League One · England |
| 2010-11-02 | SouthamptonvDag and RedLeague One · England | 4–0 | League One · England |
| 2010-10-30 | Notts CountyvSouthamptonLeague One · England | 1–3 | League One · England |
| 2010-10-23 | SouthamptonvOldhamLeague One · England | 2–1 | League One · England |
| 2010-10-16 | HuddersfieldvSouthamptonLeague One · England | 2–0 | League One · England |
| 2010-10-09 | SouthamptonvTranmereLeague One · England | 2–0 | League One · England |
| 2010-10-02 | SouthamptonvBournemouthLeague One · England | 2–0 | League One · England |
| 2010-09-28 | YeovilvSouthamptonLeague One · England | 1–1 | League One · England |
| 2010-09-25 | Sheffield WedsvSouthamptonLeague One · England | 0–1 | League One · England |
| 2010-09-18 | SouthamptonvColchesterLeague One · England | 0–0 | League One · England |
| 2010-09-15 | Milton Keynes DonsvSouthamptonLeague One · England | 2–0 | League One · England |
| 2010-09-11 | SwindonvSouthamptonLeague One · England | 1–0 | League One · England |
| 2010-09-04 | SouthamptonvRochdaleLeague One · England | 0–2 | League One · England |
| 2010-08-28 | Bristol RvsvSouthamptonLeague One · England | 0–4 | League One · England |
| 2010-08-21 | SouthamptonvLeyton OrientLeague One · England | 1–1 | League One · England |
| 2010-08-07 | SouthamptonvPlymouthLeague One · England | 0–1 | League One · England |
| 2010-05-08 | SouthamptonvSouthendLeague One · England | 3–1 | League One · England |
| 2010-05-01 | GillinghamvSouthamptonLeague One · England | 2–1 | League One · England |
| 2010-04-24 | SouthamptonvCarlisleLeague One · England | 3–2 | League One · England |
| 2010-04-20 | SouthamptonvOldhamLeague One · England | 0–0 | League One · England |
| 2010-04-17 | YeovilvSouthamptonLeague One · England | 0–1 | League One · England |
| 2010-04-13 | Bristol RvsvSouthamptonLeague One · England | 1–5 | League One · England |
| 2010-04-10 | SouthamptonvCharltonLeague One · England | 1–0 | League One · England |
| 2010-04-05 | SouthamptonvLeyton OrientLeague One · England | 2–1 | League One · England |
| 2010-04-01 | BrightonvSouthamptonLeague One · England | 2–2 | League One · England |
| 2010-03-23 | SouthamptonvHartlepoolLeague One · England | 3–2 | League One · England |
| 2010-03-20 | Milton Keynes DonsvSouthamptonLeague One · England | 0–3 | League One · England |
| 2010-03-16 | SouthamptonvSwindonLeague One · England | 0–1 | League One · England |
| 2010-03-13 | SouthamptonvLeedsLeague One · England | 1–0 | League One · England |
| 2010-03-06 | TranmerevSouthamptonLeague One · England | 2–1 | League One · England |
| 2010-03-02 | SouthamptonvHuddersfieldLeague One · England | 5–0 | League One · England |
| 2010-02-27 | SouthamptonvWalsallLeague One · England | 5–1 | League One · England |
| 2010-02-23 | WycombevSouthamptonLeague One · England | 0–0 | League One · England |
| 2010-02-20 | NorwichvSouthamptonLeague One · England | 0–2 | League One · England |
| 2010-02-06 | ExetervSouthamptonLeague One · England | 1–1 | League One · England |
| 2010-01-30 | SouthamptonvStockportLeague One · England | 2–0 | League One · England |
| 2010-01-26 | BrentfordvSouthamptonLeague One · England | 1–1 | League One · England |
| 2010-01-16 | MillwallvSouthamptonLeague One · England | 1–1 | League One · England |