| 2022-11-12 | Schalke 04vBayern MunichBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-11-09 | Schalke 04vMainzBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-11-05 | Werder BremenvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-10-30 | Schalke 04vFreiburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-10-23 | HerthavSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-10-14 | Schalke 04vHoffenheimBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-10-08 | LeverkusenvSchalke 04Bundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-10-02 | Schalke 04vAugsburgBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2022-09-17 | DortmundvSchalke 04Bundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-09-10 | Schalke 04vBochumBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-09-03 | StuttgartvSchalke 04Bundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-08-27 | Schalke 04vUnion BerlinBundesliga · Germany | 1–6 | Bundesliga · Germany |
| 2022-08-20 | WolfsburgvSchalke 04Bundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-08-13 | Schalke 04vM'gladbachBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-08-07 | FC KolnvSchalke 04Bundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-05-15 | NurnbergvSchalke 042. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-05-07 | Schalke 04vSt Pauli2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2022-04-29 | SandhausenvSchalke 042. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-04-23 | Schalke 04vWerder Bremen2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2022-04-17 | DarmstadtvSchalke 042. Bundesliga · Germany | 2–5 | 2. Bundesliga · Germany |
| 2022-04-09 | Schalke 04vHeidenheim2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-01 | DresdenvSchalke 042. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-03-19 | Schalke 04vHannover2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-03-13 | IngolstadtvSchalke 042. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2022-03-05 | Schalke 04vHansa Rostock2. Bundesliga · Germany | 3–4 | 2. Bundesliga · Germany |
| 2022-02-26 | KarlsruhevSchalke 042. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-18 | Schalke 04vPaderborn2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-13 | Fortuna DusseldorfvSchalke 042. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-02-05 | Schalke 04vRegensburg2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-01-22 | Erzgebirge AuevSchalke 042. Bundesliga · Germany | 0–5 | 2. Bundesliga · Germany |
| 2022-01-16 | Schalke 04vHolstein Kiel2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |