| 2022-10-17 | Santos LagunavTolucaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-10-14 | TolucavSantos LagunaLiga MX · Mexico | 4–3 | Liga MX · Mexico |
| 2022-10-03 | Santos LagunavMazatlan FCLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2022-09-19 | Santos LagunavJuarezLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-09-15 | Club AmericavSantos LagunaLiga MX · Mexico | 3–3 | Liga MX · Mexico |
| 2022-09-10 | QueretarovSantos LagunaLiga MX · Mexico | 3–3 | Liga MX · Mexico |
| 2022-09-07 | Santos LagunavNecaxaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-09-03 | PachucavSantos LagunaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-08-29 | Santos LagunavAtl. San LuisLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2022-08-26 | Club TijuanavSantos LagunaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2022-08-21 | UNAM PumasvSantos LagunaLiga MX · Mexico | 1–5 | Liga MX · Mexico |
| 2022-08-19 | Santos LagunavClub LeonLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-08-15 | Tigres UANLvSantos LagunaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-08-07 | Santos LagunavCruz AzulLiga MX · Mexico | 4–0 | Liga MX · Mexico |
| 2022-08-01 | Santos LagunavAtlasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-07-23 | TolucavSantos LagunaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-07-17 | Santos LagunavGuadalajara ChivasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-07-09 | PueblavSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-07-04 | Santos LagunavMonterreyLiga MX · Mexico | 4–3 | Liga MX · Mexico |
| 2022-05-01 | Atl. San LuisvSantos LagunaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-04-25 | Santos LagunavClub LeonLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-20 | Mazatlan FCvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-17 | Santos LagunavQueretaroLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-10 | MonterreyvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-04 | Santos LagunavPachucaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-03-19 | PueblavSantos LagunaLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2022-03-14 | Santos LagunavClub TijuanaLiga MX · Mexico | 4–0 | Liga MX · Mexico |
| 2022-03-06 | Guadalajara ChivasvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-03-03 | Santos LagunavUNAM PumasLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2022-02-28 | Cruz AzulvSantos LagunaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-02-19 | JuarezvSantos LagunaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-02-13 | Santos LagunavClub AmericaLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2022-02-07 | AtlasvSantos LagunaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-01-24 | Santos LagunavNecaxaLiga MX · Mexico | 1–4 | Liga MX · Mexico |
| 2022-01-16 | TolucavSantos LagunaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-01-13 | Santos LagunavTigres UANLLiga MX · Mexico | 1–1 | Liga MX · Mexico |