| 2022-10-09 | Seattle SoundersvSan Jose EarthquakesMLS · United States | 2–2 | MLS · United States |
| 2022-10-02 | San Jose EarthquakesvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-09-25 | San Jose EarthquakesvLos Angeles GalaxyMLS · United States | 2–3 | MLS · United States |
| 2022-09-18 | San Jose EarthquakesvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2022-09-15 | Colorado RapidsvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2022-09-11 | FC CincinnativSan Jose EarthquakesMLS · United States | 6–0 | MLS · United States |
| 2022-09-05 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 2–0 | MLS · United States |
| 2022-08-28 | Sporting Kansas CityvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2022-08-21 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-08-14 | FC DallasvSan Jose EarthquakesMLS · United States | 4–1 | MLS · United States |
| 2022-08-07 | Austin FCvSan Jose EarthquakesMLS · United States | 3–3 | MLS · United States |
| 2022-08-04 | San Jose EarthquakesvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-07-31 | San Jose EarthquakesvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2022-07-24 | Portland TimbersvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2022-07-18 | San Jose EarthquakesvHouston DynamoMLS · United States | 1–2 | MLS · United States |
| 2022-07-14 | Los Angeles GalaxyvSan Jose EarthquakesMLS · United States | 2–3 | MLS · United States |
| 2022-07-10 | Toronto FCvSan Jose EarthquakesMLS · United States | 2–2 | MLS · United States |
| 2022-07-04 | San Jose EarthquakesvChicago FireMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | Real Salt LakevSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2022-06-12 | Nashville SCvSan Jose EarthquakesMLS · United States | 0–0 | MLS · United States |
| 2022-05-28 | Los Angeles FCvSan Jose EarthquakesMLS · United States | 3–2 | MLS · United States |
| 2022-05-23 | San Jose EarthquakesvSporting Kansas CityMLS · United States | 1–1 | MLS · United States |
| 2022-05-19 | San Jose EarthquakesvPortland TimbersMLS · United States | 3–2 | MLS · United States |
| 2022-05-15 | Vancouver WhitecapsvSan Jose EarthquakesMLS · United States | 3–3 | MLS · United States |
| 2022-05-08 | San Jose EarthquakesvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2022-05-01 | New York CityvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2022-04-24 | San Jose EarthquakesvSeattle SoundersMLS · United States | 4–3 | MLS · United States |
| 2022-04-16 | San Jose EarthquakesvNashville SCMLS · United States | 2–2 | MLS · United States |
| 2022-04-10 | Houston DynamovSan Jose EarthquakesMLS · United States | 4–3 | MLS · United States |
| 2022-04-03 | San Jose EarthquakesvAustin FCMLS · United States | 2–2 | MLS · United States |
| 2022-03-20 | Minnesota UnitedvSan Jose EarthquakesMLS · United States | 1–0 | MLS · United States |
| 2022-03-13 | Philadelphia UnionvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2022-03-05 | San Jose EarthquakesvColumbus CrewMLS · United States | 3–3 | MLS · United States |
| 2022-02-26 | San Jose EarthquakesvNew York Red BullsMLS · United States | 1–3 | MLS · United States |