| 2026-09-14 | San Diego FCvPhiladelphia UnionMLS · United States | 0–5 | MLS · United States |
| 2026-09-14 | San Diego FCvPhiladelphia UnionMLS | 0–5 | MLS |
| 2026-09-10 | San Diego FCvSan Jose EarthquakesMLS · United States | 2–3 | MLS · United States |
| 2026-09-10 | San Diego FCvSan Jose EarthquakesMLS | 2–3 | MLS |
| 2026-09-06 | Orlando CityvSan Diego FCMLS · United States | 1–0 | MLS · United States |
| 2026-09-05 | Orlando City SCvSan Diego FCMLS | 1–0 | MLS |
| 2026-08-30 | San Diego FCvLos Angeles GalaxyMLS · United States | 3–1 | MLS · United States |
| 2026-08-30 | San Diego FCvLos Angeles GalaxyMLS | 3–1 | MLS |
| 2026-08-23 | San Diego FCvColorado RapidsMLS | 3–0 | MLS |
| 2026-08-23 | San Diego FCvColorado RapidsMLS · United States | 3–0 | MLS · United States |
| 2026-08-20 | Portland TimbersvSan Diego FCMLS | 3–1 | MLS |
| 2026-08-20 | Portland TimbersvSan Diego FCMLS · United States | 3–1 | MLS · United States |
| 2026-08-16 | Los Angeles FCvSan Diego FCMLS · United States | 0–1 | MLS · United States |
| 2026-08-13 | San Diego FCvPueblaLEAGUESCUP | 3–2 | LEAGUESCUP |
| 2026-08-10 | San Diego FCvClub TijuanaLEAGUESCUP | 1–0 | LEAGUESCUP |
| 2026-08-07 | Club AmericavSan Diego FCLEAGUESCUP | 3–1 | LEAGUESCUP |
| 2026-08-02 | Minnesota United FCvSan Diego FCMLS | 1–1 | MLS |
| 2026-08-02 | Minnesota UnitedvSan Diego FCMLS · United States | 1–1 | MLS · United States |
| 2026-07-26 | San Diego FCvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2026-07-23 | Colorado RapidsvSan Diego FCMLS · United States | 1–0 | MLS · United States |
| 2026-05-24 | San Diego FCvVancouver WhitecapsMLS · United States | 2–4 | MLS · United States |
| 2026-05-17 | San Diego FCvFC CincinnatiMLS · United States | 3–3 | MLS · United States |
| 2026-05-14 | San Diego FCvAustin FCMLS · United States | 5–0 | MLS · United States |
| 2026-05-10 | Seattle SoundersvSan Diego FCMLS · United States | 1–1 | MLS · United States |
| 2026-05-03 | San Diego FCvLos Angeles FCMLS · United States | 2–2 | MLS · United States |
| 2026-04-26 | San Diego FCvPortland TimbersMLS · United States | 1–2 | MLS · United States |
| 2026-04-23 | Houston DynamovSan Diego FCMLS · United States | 1–0 | MLS · United States |
| 2026-04-19 | Real Salt LakevSan Diego FCMLS · United States | 4–2 | MLS · United States |
| 2026-04-12 | San Diego FCvMinnesota UnitedMLS · United States | 1–2 | MLS · United States |
| 2026-04-05 | San Jose EarthquakesvSan Diego FCMLS · United States | 3–0 | MLS · United States |
| 2026-03-22 | San Diego FCvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2026-03-15 | FC DallasvSan Diego FCMLS · United States | 3–3 | MLS · United States |
| 2026-03-08 | Sporting Kansas CityvSan Diego FCMLS · United States | 0–1 | MLS · United States |
| 2026-03-02 | San Diego FCvSt. Louis CityMLS · United States | 2–0 | MLS · United States |
| 2026-02-22 | San Diego FCvCF MontrealMLS · United States | 5–0 | MLS · United States |