| 2022-11-12 | Werder BremenvRB LeipzigBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-11-09 | RB LeipzigvFreiburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-11-05 | HoffenheimvRB LeipzigBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2022-10-29 | RB LeipzigvLeverkusenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-10-22 | AugsburgvRB LeipzigBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2022-10-15 | RB LeipzigvHerthaBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-10-08 | MainzvRB LeipzigBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-10-01 | RB LeipzigvBochumBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-09-17 | M'gladbachvRB LeipzigBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-09-10 | RB LeipzigvDortmundBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-09-03 | Ein FrankfurtvRB LeipzigBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-08-27 | RB LeipzigvWolfsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-08-20 | Union BerlinvRB LeipzigBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-08-13 | RB LeipzigvFC KolnBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-08-07 | StuttgartvRB LeipzigBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-05-14 | BielefeldvRB LeipzigBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-05-08 | RB LeipzigvAugsburgBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-05-02 | M'gladbachvRB LeipzigBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-04-23 | RB LeipzigvUnion BerlinBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-04-17 | LeverkusenvRB LeipzigBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-04-10 | RB LeipzigvHoffenheimBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-04-02 | DortmundvRB LeipzigBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-03-20 | RB LeipzigvEin FrankfurtBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-03-13 | Greuther FurthvRB LeipzigBundesliga · Germany | 1–6 | Bundesliga · Germany |
| 2022-03-05 | RB LeipzigvFreiburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-27 | BochumvRB LeipzigBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-02-20 | HerthavRB LeipzigBundesliga · Germany | 1–6 | Bundesliga · Germany |
| 2022-02-11 | RB LeipzigvFC KolnBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-02-05 | Bayern MunichvRB LeipzigBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-01-23 | RB LeipzigvWolfsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-01-15 | StuttgartvRB LeipzigBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-01-08 | RB LeipzigvMainzBundesliga · Germany | 4–1 | Bundesliga · Germany |