| 2022-10-17 | CF MontrealvOrlando CityMLS · United States | 2–0 | MLS · United States |
| 2022-10-09 | Orlando CityvColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2022-10-06 | Inter MiamivOrlando CityMLS · United States | 4–1 | MLS · United States |
| 2022-10-02 | New York CityvOrlando CityMLS · United States | 2–1 | MLS · United States |
| 2022-09-18 | Orlando CityvToronto FCMLS · United States | 4–0 | MLS · United States |
| 2022-09-14 | Orlando CityvAtlanta UtdMLS · United States | 0–1 | MLS · United States |
| 2022-09-11 | Philadelphia UnionvOrlando CityMLS · United States | 5–1 | MLS · United States |
| 2022-09-01 | Orlando CityvSeattle SoundersMLS · United States | 3–2 | MLS · United States |
| 2022-08-29 | Orlando CityvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2022-08-22 | CharlottevOrlando CityMLS · United States | 1–2 | MLS · United States |
| 2022-08-13 | New York Red BullsvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-08-07 | Orlando CityvNew England RevolutionMLS · United States | 0–3 | MLS · United States |
| 2022-07-31 | DC UnitedvOrlando CityMLS · United States | 2–1 | MLS · United States |
| 2022-07-24 | Orlando CityvPhiladelphia UnionMLS · United States | 0–1 | MLS · United States |
| 2022-07-17 | Atlanta UtdvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-07-14 | Colorado RapidsvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-07-10 | Orlando CityvInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-07-05 | Orlando CityvDC UnitedMLS · United States | 3–5 | MLS · United States |
| 2022-06-25 | FC CincinnativOrlando CityMLS · United States | 1–0 | MLS · United States |
| 2022-06-19 | Orlando CityvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-06-16 | New England RevolutionvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-05-29 | Orlando CityvFC DallasMLS · United States | 1–3 | MLS · United States |
| 2022-05-23 | Austin FCvOrlando CityMLS · United States | 2–2 | MLS · United States |
| 2022-05-14 | Toronto FCvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-05-07 | CF MontrealvOrlando CityMLS · United States | 4–1 | MLS · United States |
| 2022-05-01 | Orlando CityvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-24 | Orlando CityvNew York Red BullsMLS · United States | 0–3 | MLS · United States |
| 2022-04-17 | Columbus CrewvOrlando CityMLS · United States | 0–2 | MLS · United States |
| 2022-04-09 | Orlando CityvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Orlando CityvLos Angeles FCMLS · United States | 2–4 | MLS · United States |
| 2022-03-27 | Portland TimbersvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2022-03-19 | Los Angeles GalaxyvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-03-13 | Orlando CityvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2022-03-05 | Chicago FirevOrlando CityMLS · United States | 0–0 | MLS · United States |
| 2022-02-27 | Orlando CityvCF MontrealMLS · United States | 2–0 | MLS · United States |