| 2010-12-11 | StevenagevNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2010-12-04 | NorthamptonvStockportLeague Two · England | 2–0 | League Two · England |
| 2010-11-23 | RotherhamvNorthamptonLeague Two · England | 2–2 | League Two · England |
| 2010-11-20 | BarnetvNorthamptonLeague Two · England | 4–1 | League Two · England |
| 2010-11-13 | NorthamptonvPort ValeLeague Two · England | 0–0 | League Two · England |
| 2010-11-02 | LincolnvNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2010-10-30 | NorthamptonvGillinghamLeague Two · England | 2–1 | League Two · England |
| 2010-10-23 | OxfordvNorthamptonLeague Two · England | 3–1 | League Two · England |
| 2010-10-16 | NorthamptonvHerefordLeague Two · England | 3–4 | League Two · England |
| 2010-10-09 | CheltenhamvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2010-10-02 | MacclesfieldvNorthamptonLeague Two · England | 2–0 | League Two · England |
| 2010-09-28 | NorthamptonvChesterfieldLeague Two · England | 1–2 | League Two · England |
| 2010-09-25 | NorthamptonvBradfordLeague Two · England | 2–0 | League Two · England |
| 2010-09-18 | ShrewsburyvNorthamptonLeague Two · England | 3–1 | League Two · England |
| 2010-09-11 | NorthamptonvSouthendLeague Two · England | 2–1 | League Two · England |
| 2010-09-04 | AldershotvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2010-08-28 | NorthamptonvWycombeLeague Two · England | 1–1 | League Two · England |
| 2010-08-21 | BuryvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2010-08-14 | NorthamptonvAccringtonLeague Two · England | 0–0 | League Two · England |
| 2010-08-07 | TorquayvNorthamptonLeague Two · England | 3–0 | League Two · England |
| 2010-05-08 | NorthamptonvBuryLeague Two · England | 1–1 | League Two · England |
| 2010-05-01 | BradfordvNorthamptonLeague Two · England | 2–0 | League Two · England |
| 2010-04-24 | NorthamptonvShrewsburyLeague Two · England | 2–0 | League Two · England |
| 2010-04-17 | RochdalevNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2010-04-13 | RotherhamvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2010-04-10 | NorthamptonvNotts CountyLeague Two · England | 0–1 | League Two · England |
| 2010-04-05 | NorthamptonvTorquayLeague Two · England | 0–0 | League Two · England |
| 2010-04-02 | GrimsbyvNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2010-03-27 | LincolnvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2010-03-20 | NorthamptonvMorecambeLeague Two · England | 2–0 | League Two · England |
| 2010-03-13 | NorthamptonvDarlingtonLeague Two · England | 2–0 | League Two · England |
| 2010-03-06 | Port ValevNorthamptonLeague Two · England | 1–3 | League Two · England |
| 2010-02-27 | NorthamptonvCheltenhamLeague Two · England | 2–1 | League Two · England |
| 2010-02-23 | HerefordvNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2010-02-20 | CrewevNorthamptonLeague Two · England | 3–2 | League Two · England |
| 2010-02-12 | NorthamptonvAldershotLeague Two · England | 0–3 | League Two · England |
| 2010-02-09 | NorthamptonvAccringtonLeague Two · England | 4–0 | League Two · England |
| 2010-02-06 | Dag and RedvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2010-01-30 | NorthamptonvBurtonLeague Two · England | 1–1 | League Two · England |
| 2010-01-26 | DarlingtonvNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2010-01-23 | NorthamptonvChesterfieldLeague Two · England | 0–0 | League Two · England |
| 2010-01-20 | MacclesfieldvNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2010-01-02 | BournemouthvNorthamptonLeague Two · England | 0–2 | League Two · England |