| 2021-12-12 | Lokomotiv MoscowvUfaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-12-04 | Lokomotiv MoscowvUralPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-11-29 | Arsenal TulavLokomotiv MoscowPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-11-20 | Lokomotiv MoscowvAkhmat GroznyPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-11-07 | Spartak MoscowvLokomotiv MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-30 | Pari NNvLokomotiv MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-10-25 | Lokomotiv MoscowvSochiPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-10-16 | Rubin KazanvLokomotiv MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-10-03 | Lokomotiv MoscowvFK RostovPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-09-25 | KhimkivLokomotiv MoscowPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-09-20 | UralvLokomotiv MoscowPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-09-11 | Lokomotiv MoscowvKrylya SovetovPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-08-27 | Dynamo MoscowvLokomotiv MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-22 | Lokomotiv MoscowvKrasnodarPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-15 | Lokomotiv MoscowvZenitPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-06 | UfavLokomotiv MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-07-31 | CSKA MoscowvLokomotiv MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-07-24 | Lokomotiv MoscowvArsenal TulaPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-05-16 | Lokomotiv MoscowvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-08 | Lokomotiv MoscowvDynamo MoscowPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-05-02 | ZenitvLokomotiv MoscowPremier League · Russia | 6–1 | Premier League · Russia |
| 2021-04-24 | TambovvLokomotiv MoscowPremier League · Russia | 2–5 | Premier League · Russia |
| 2021-04-17 | Lokomotiv MoscowvFK RostovPremier League · Russia | 4–1 | Premier League · Russia |
| 2021-04-11 | Lokomotiv MoscowvSpartak MoscowPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-04-03 | R. VolgogradvLokomotiv MoscowPremier League · Russia | 0–2 | Premier League · Russia |
| 2021-03-18 | UfavLokomotiv MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-03-14 | Lokomotiv MoscowvSochiPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-03-08 | Arsenal TulavLokomotiv MoscowPremier League · Russia | 0–3 | Premier League · Russia |
| 2021-02-27 | Lokomotiv MoscowvCSKA MoscowPremier League · Russia | 2–0 | Premier League · Russia |