| 2022-11-12 | LeverkusenvStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-11-09 | FC KolnvLeverkusenBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-11-06 | LeverkusenvUnion BerlinBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2022-10-29 | RB LeipzigvLeverkusenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-10-22 | LeverkusenvWolfsburgBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-10-15 | Ein FrankfurtvLeverkusenBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2022-10-08 | LeverkusenvSchalke 04Bundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-09-30 | Bayern MunichvLeverkusenBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-09-17 | LeverkusenvWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-09-10 | HerthavLeverkusenBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-09-03 | LeverkusenvFreiburgBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2022-08-27 | MainzvLeverkusenBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-08-20 | LeverkusenvHoffenheimBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-08-13 | LeverkusenvAugsburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-08-06 | DortmundvLeverkusenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-05-14 | LeverkusenvFreiburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-05-07 | HoffenheimvLeverkusenBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2022-05-02 | LeverkusenvEin FrankfurtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-04-23 | Greuther FurthvLeverkusenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-17 | LeverkusenvRB LeipzigBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-04-10 | BochumvLeverkusenBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-04-02 | LeverkusenvHerthaBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-03-20 | WolfsburgvLeverkusenBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-03-13 | LeverkusenvFC KolnBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-03-05 | Bayern MunichvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-26 | LeverkusenvBielefeldBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-02-18 | MainzvLeverkusenBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-02-12 | LeverkusenvStuttgartBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2022-02-06 | DortmundvLeverkusenBundesliga · Germany | 2–5 | Bundesliga · Germany |
| 2022-01-22 | LeverkusenvAugsburgBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2022-01-15 | M'gladbachvLeverkusenBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-01-08 | LeverkusenvUnion BerlinBundesliga · Germany | 2–2 | Bundesliga · Germany |