| 2022-11-12 | HoffenheimvWolfsburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-11-09 | Ein FrankfurtvHoffenheimBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2022-11-05 | HoffenheimvRB LeipzigBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2022-10-30 | FC KolnvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-10-22 | HoffenheimvBayern MunichBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-10-14 | Schalke 04vHoffenheimBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-10-07 | HoffenheimvWerder BremenBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-10-02 | HerthavHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-09-18 | HoffenheimvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-09-10 | HoffenheimvMainzBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2022-09-02 | DortmundvHoffenheimBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-08-27 | HoffenheimvAugsburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-08-20 | LeverkusenvHoffenheimBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-08-13 | HoffenheimvBochumBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-08-06 | M'gladbachvHoffenheimBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-05-14 | M'gladbachvHoffenheimBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2022-05-07 | HoffenheimvLeverkusenBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2022-04-30 | HoffenheimvFreiburgBundesliga · Germany | 3–4 | Bundesliga · Germany |
| 2022-04-23 | Ein FrankfurtvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-04-17 | HoffenheimvGreuther FurthBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-04-10 | RB LeipzigvHoffenheimBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-04-02 | HoffenheimvBochumBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-03-19 | HerthavHoffenheimBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-03-12 | HoffenheimvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-06 | FC KolnvHoffenheimBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-02-25 | HoffenheimvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-02-19 | WolfsburgvHoffenheimBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-02-13 | HoffenheimvBielefeldBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-02-05 | MainzvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-01-22 | HoffenheimvDortmundBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2022-01-15 | Union BerlinvHoffenheimBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-01-08 | HoffenheimvAugsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |