| 2021-12-11 | ExetervTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-12-07 | ExetervNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-11-27 | RochdalevExeterLeague Two · England | 1–1 | League Two · England |
| 2021-11-23 | ColchestervExeterLeague Two · England | 3–1 | League Two · England |
| 2021-11-20 | ExetervCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-11-13 | ExetervOldhamLeague Two · England | 2–1 | League Two · England |
| 2021-10-30 | SalfordvExeterLeague Two · England | 1–2 | League Two · England |
| 2021-10-23 | ExetervMansfieldLeague Two · England | 2–1 | League Two · England |
| 2021-10-19 | Crawley TownvExeterLeague Two · England | 1–3 | League Two · England |
| 2021-10-16 | ExetervNewport CountyLeague Two · England | 2–2 | League Two · England |
| 2021-10-09 | StevenagevExeterLeague Two · England | 2–2 | League Two · England |
| 2021-10-02 | ExetervWalsallLeague Two · England | 2–2 | League Two · England |
| 2021-09-25 | HartlepoolvExeterLeague Two · England | 1–1 | League Two · England |
| 2021-09-18 | ExetervSuttonLeague Two · England | 2–0 | League Two · England |
| 2021-09-11 | ScunthorpevExeterLeague Two · England | 0–4 | League Two · England |
| 2021-09-04 | ExetervForest GreenLeague Two · England | 0–0 | League Two · England |
| 2021-08-28 | HarrogatevExeterLeague Two · England | 1–1 | League Two · England |
| 2021-08-21 | ExetervBristol RvsLeague Two · England | 4–1 | League Two · England |
| 2021-08-17 | BarrowvExeterLeague Two · England | 0–0 | League Two · England |
| 2021-08-14 | Leyton OrientvExeterLeague Two · England | 3–0 | League Two · England |
| 2021-08-07 | ExetervBradfordLeague Two · England | 0–0 | League Two · England |
| 2021-05-08 | ExetervBarrowLeague Two · England | 1–1 | League Two · England |
| 2021-05-01 | BoltonvExeterLeague Two · England | 1–2 | League Two · England |
| 2021-04-27 | ExetervGrimsbyLeague Two · England | 3–2 | League Two · England |
| 2021-04-24 | ExetervNewport CountyLeague Two · England | 0–0 | League Two · England |
| 2021-04-20 | Forest GreenvExeterLeague Two · England | 0–0 | League Two · England |
| 2021-04-17 | ExetervSouthendLeague Two · England | 0–0 | League Two · England |
| 2021-04-13 | BarrowvExeterLeague Two · England | 2–1 | League Two · England |
| 2021-04-10 | CambridgevExeterLeague Two · England | 1–4 | League Two · England |
| 2021-04-05 | ExetervMansfieldLeague Two · England | 0–0 | League Two · England |
| 2021-04-02 | Port ValevExeterLeague Two · England | 1–0 | League Two · England |
| 2021-03-27 | ExetervSalfordLeague Two · England | 1–0 | League Two · England |
| 2021-03-23 | OldhamvExeterLeague Two · England | 2–1 | League Two · England |
| 2021-03-20 | TranmerevExeterLeague Two · England | 2–1 | League Two · England |
| 2021-03-13 | ExetervCheltenhamLeague Two · England | 0–1 | League Two · England |
| 2021-03-09 | ScunthorpevExeterLeague Two · England | 0–2 | League Two · England |
| 2021-03-06 | ExetervLeyton OrientLeague Two · England | 4–0 | League Two · England |
| 2021-03-02 | ExetervWalsallLeague Two · England | 0–0 | League Two · England |
| 2021-02-27 | Crawley TownvExeterLeague Two · England | 2–0 | League Two · England |
| 2021-02-23 | ColchestervExeterLeague Two · England | 1–2 | League Two · England |
| 2021-02-16 | Newport CountyvExeterLeague Two · England | 1–1 | League Two · England |
| 2021-02-06 | ExetervBradfordLeague Two · England | 3–2 | League Two · England |
| 2021-02-02 | StevenagevExeterLeague Two · England | 0–1 | League Two · England |
| 2021-01-30 | CarlislevExeterLeague Two · England | 1–0 | League Two · England |
| 2021-01-26 | ExetervMorecambeLeague Two · England | 0–2 | League Two · England |
| 2021-01-23 | ExetervStevenageLeague Two · England | 3–1 | League Two · England |
| 2021-01-19 | HarrogatevExeterLeague Two · England | 0–0 | League Two · England |
| 2021-01-12 | ExetervBoltonLeague Two · England | 1–1 | League Two · England |