| 2021-12-28 | Crystal PalacevNorwichPremier League · England | 3–0 | Premier League · England |
| 2021-12-26 | TottenhamvCrystal PalacePremier League · England | 3–0 | Premier League · England |
| 2021-12-15 | Crystal PalacevSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2021-12-12 | Crystal PalacevEvertonPremier League · England | 3–1 | Premier League · England |
| 2021-12-05 | Man UnitedvCrystal PalacePremier League · England | 1–0 | Premier League · England |
| 2021-11-30 | LeedsvCrystal PalacePremier League · England | 1–0 | Premier League · England |
| 2021-11-27 | Crystal PalacevAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-11-20 | BurnleyvCrystal PalacePremier League · England | 3–3 | Premier League · England |
| 2021-11-06 | Crystal PalacevWolvesPremier League · England | 2–0 | Premier League · England |
| 2021-10-30 | Man CityvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2021-10-23 | Crystal PalacevNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-10-18 | ArsenalvCrystal PalacePremier League · England | 2–2 | Premier League · England |
| 2021-10-03 | Crystal PalacevLeicesterPremier League · England | 2–2 | Premier League · England |
| 2021-09-27 | Crystal PalacevBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-09-18 | LiverpoolvCrystal PalacePremier League · England | 3–0 | Premier League · England |
| 2021-09-11 | Crystal PalacevTottenhamPremier League · England | 3–0 | Premier League · England |
| 2021-08-28 | West HamvCrystal PalacePremier League · England | 2–2 | Premier League · England |
| 2021-08-21 | Crystal PalacevBrentfordPremier League · England | 0–0 | Premier League · England |
| 2021-08-14 | ChelseavCrystal PalacePremier League · England | 3–0 | Premier League · England |
| 2021-05-23 | LiverpoolvCrystal PalacePremier League · England | 2–0 | Premier League · England |
| 2021-05-19 | Crystal PalacevArsenalPremier League · England | 1–3 | Premier League · England |
| 2021-05-16 | Crystal PalacevAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-05-11 | SouthamptonvCrystal PalacePremier League · England | 3–1 | Premier League · England |
| 2021-05-08 | Sheffield UnitedvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2021-05-01 | Crystal PalacevMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-04-26 | LeicestervCrystal PalacePremier League · England | 2–1 | Premier League · England |
| 2021-04-10 | Crystal PalacevChelseaPremier League · England | 1–4 | Premier League · England |
| 2021-04-05 | EvertonvCrystal PalacePremier League · England | 1–1 | Premier League · England |
| 2021-03-13 | Crystal PalacevWest BromPremier League · England | 1–0 | Premier League · England |
| 2021-03-07 | TottenhamvCrystal PalacePremier League · England | 4–1 | Premier League · England |
| 2021-03-03 | Crystal PalacevMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-02-28 | Crystal PalacevFulhamPremier League · England | 0–0 | Premier League · England |
| 2021-02-22 | BrightonvCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2021-02-13 | Crystal PalacevBurnleyPremier League · England | 0–3 | Premier League · England |
| 2021-02-08 | LeedsvCrystal PalacePremier League · England | 2–0 | Premier League · England |
| 2021-02-02 | NewcastlevCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2021-01-30 | Crystal PalacevWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-01-26 | Crystal PalacevWest HamPremier League · England | 2–3 | Premier League · England |
| 2021-01-17 | Man CityvCrystal PalacePremier League · England | 4–0 | Premier League · England |
| 2021-01-14 | ArsenalvCrystal PalacePremier League · England | 0–0 | Premier League · England |
| 2021-01-02 | Crystal PalacevSheffield UnitedPremier League · England | 2–0 | Premier League · England |