| 2025-11-08 | FC CincinnativColumbus CrewMLS · United States | 2–1 | MLS · United States |
| 2025-11-02 | Columbus CrewvFC CincinnatiMLS · United States | 4–0 | MLS · United States |
| 2025-10-27 | FC CincinnativColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2025-10-18 | Columbus CrewvNew York Red BullsMLS · United States | 3–1 | MLS · United States |
| 2025-10-05 | Orlando CityvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2025-09-28 | Chicago FirevColumbus CrewMLS · United States | 2–0 | MLS · United States |
| 2025-09-21 | Columbus CrewvToronto FCMLS · United States | 1–1 | MLS · United States |
| 2025-09-18 | New York CityvColumbus CrewMLS · United States | 3–2 | MLS · United States |
| 2025-09-14 | Atlanta UtdvColumbus CrewMLS · United States | 4–5 | MLS · United States |
| 2025-08-31 | New York Red BullsvColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2025-08-24 | Columbus CrewvNew England RevolutionMLS · United States | 1–2 | MLS · United States |
| 2025-08-17 | Toronto FCvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2025-07-26 | Columbus CrewvOrlando CityMLS · United States | 1–3 | MLS · United States |
| 2025-07-20 | Columbus CrewvDC UnitedMLS · United States | 2–1 | MLS · United States |
| 2025-07-17 | Nashville SCvColumbus CrewMLS · United States | 3–0 | MLS · United States |
| 2025-07-13 | FC CincinnativColumbus CrewMLS · United States | 2–4 | MLS · United States |
| 2025-07-06 | Seattle SoundersvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2025-06-29 | Columbus CrewvPhiladelphia UnionMLS · United States | 1–0 | MLS · United States |
| 2025-06-26 | Columbus CrewvAtlanta UtdMLS · United States | 3–1 | MLS · United States |
| 2025-06-15 | Columbus CrewvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2025-06-01 | Inter MiamivColumbus CrewMLS · United States | 5–1 | MLS · United States |
| 2025-05-29 | Columbus CrewvNashville SCMLS · United States | 2–2 | MLS · United States |
| 2025-05-25 | CharlottevColumbus CrewMLS · United States | 3–2 | MLS · United States |
| 2025-05-18 | Columbus CrewvFC CincinnatiMLS · United States | 1–1 | MLS · United States |
| 2025-05-15 | CF MontrealvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2025-05-11 | Philadelphia UnionvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2025-05-04 | Columbus CrewvCharlotteMLS · United States | 4–2 | MLS · United States |
| 2025-04-27 | Columbus CrewvSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2025-04-19 | Columbus CrewvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2025-04-14 | St. Louis CityvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2025-04-06 | Columbus CrewvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2025-03-29 | DC UnitedvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2025-03-22 | Columbus CrewvNew York CityMLS · United States | 0–0 | MLS · United States |
| 2025-03-16 | San Diego FCvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2025-03-08 | Columbus CrewvHouston DynamoMLS · United States | 0–0 | MLS · United States |
| 2025-03-02 | New England RevolutionvColumbus CrewMLS · United States | 0–1 | MLS · United States |
| 2025-02-23 | Columbus CrewvChicago FireMLS · United States | 4–2 | MLS · United States |