| 2022-10-09 | New York Red BullsvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-10-06 | CharlottevColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2022-10-01 | CharlottevPhiladelphia UnionMLS · United States | 4–0 | MLS · United States |
| 2022-09-18 | Chicago FirevCharlotteMLS · United States | 2–3 | MLS · United States |
| 2022-09-10 | CharlottevNew York CityMLS · United States | 1–0 | MLS · United States |
| 2022-09-04 | FC CincinnativCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-08-28 | CharlottevToronto FCMLS · United States | 0–2 | MLS · United States |
| 2022-08-22 | CharlottevOrlando CityMLS · United States | 1–2 | MLS · United States |
| 2022-08-18 | New York CityvCharlotteMLS · United States | 1–3 | MLS · United States |
| 2022-08-14 | Los Angeles FCvCharlotteMLS · United States | 5–0 | MLS · United States |
| 2022-08-07 | CharlottevChicago FireMLS · United States | 2–3 | MLS · United States |
| 2022-08-04 | CharlottevDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-07-24 | Toronto FCvCharlotteMLS · United States | 4–0 | MLS · United States |
| 2022-07-17 | Inter MiamivCharlotteMLS · United States | 3–2 | MLS · United States |
| 2022-07-10 | CharlottevNashville SCMLS · United States | 4–1 | MLS · United States |
| 2022-07-04 | Houston DynamovCharlotteMLS · United States | 1–2 | MLS · United States |
| 2022-07-01 | CharlottevAustin FCMLS · United States | 0–1 | MLS · United States |
| 2022-06-26 | CF MontrealvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-06-19 | Columbus CrewvCharlotteMLS · United States | 1–1 | MLS · United States |
| 2022-06-11 | CharlottevNew York Red BullsMLS · United States | 2–0 | MLS · United States |
| 2022-05-30 | Seattle SoundersvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-05-22 | CharlottevVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-05-15 | CharlottevCF MontrealMLS · United States | 0–2 | MLS · United States |
| 2022-05-07 | CharlottevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-05-01 | Orlando CityvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-24 | Colorado RapidsvCharlotteMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | New England RevolutionvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-10 | CharlottevAtlanta UtdMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | Philadelphia UnionvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-03-26 | CharlottevFC CincinnatiMLS · United States | 2–0 | MLS · United States |
| 2022-03-19 | CharlottevNew England RevolutionMLS · United States | 3–1 | MLS · United States |
| 2022-03-13 | Atlanta UtdvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-03-06 | CharlottevLos Angeles GalaxyMLS · United States | 0–1 | MLS · United States |
| 2022-02-26 | DC UnitedvCharlotteMLS · United States | 3–0 | MLS · United States |