| 2022-12-30 | West HamvBrentfordPremier League · England | 0–2 | Premier League · England |
| 2022-12-26 | BrentfordvTottenhamPremier League · England | 2–2 | Premier League · England |
| 2022-11-12 | Man CityvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2022-11-05 | Nott'm ForestvBrentfordPremier League · England | 2–2 | Premier League · England |
| 2022-10-29 | BrentfordvWolvesPremier League · England | 1–1 | Premier League · England |
| 2022-10-23 | Aston VillavBrentfordPremier League · England | 4–0 | Premier League · England |
| 2022-10-19 | BrentfordvChelseaPremier League · England | 0–0 | Premier League · England |
| 2022-10-14 | BrentfordvBrightonPremier League · England | 2–0 | Premier League · England |
| 2022-10-08 | NewcastlevBrentfordPremier League · England | 5–1 | Premier League · England |
| 2022-10-01 | BournemouthvBrentfordPremier League · England | 0–0 | Premier League · England |
| 2022-09-18 | BrentfordvArsenalPremier League · England | 0–3 | Premier League · England |
| 2022-09-03 | BrentfordvLeedsPremier League · England | 5–2 | Premier League · England |
| 2022-08-30 | Crystal PalacevBrentfordPremier League · England | 1–1 | Premier League · England |
| 2022-08-27 | BrentfordvEvertonPremier League · England | 1–1 | Premier League · England |
| 2022-08-20 | FulhamvBrentfordPremier League · England | 3–2 | Premier League · England |
| 2022-08-13 | BrentfordvMan UnitedPremier League · England | 4–0 | Premier League · England |
| 2022-08-07 | LeicestervBrentfordPremier League · England | 2–2 | Premier League · England |
| 2022-05-22 | BrentfordvLeedsPremier League · England | 1–2 | Premier League · England |
| 2022-05-15 | EvertonvBrentfordPremier League · England | 2–3 | Premier League · England |
| 2022-05-07 | BrentfordvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2022-05-02 | Man UnitedvBrentfordPremier League · England | 3–0 | Premier League · England |
| 2022-04-23 | BrentfordvTottenhamPremier League · England | 0–0 | Premier League · England |
| 2022-04-16 | WatfordvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2022-04-10 | BrentfordvWest HamPremier League · England | 2–0 | Premier League · England |
| 2022-04-02 | ChelseavBrentfordPremier League · England | 1–4 | Premier League · England |
| 2022-03-20 | LeicestervBrentfordPremier League · England | 2–1 | Premier League · England |
| 2022-03-12 | BrentfordvBurnleyPremier League · England | 2–0 | Premier League · England |
| 2022-03-05 | NorwichvBrentfordPremier League · England | 1–3 | Premier League · England |
| 2022-02-26 | BrentfordvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2022-02-19 | ArsenalvBrentfordPremier League · England | 2–1 | Premier League · England |
| 2022-02-12 | BrentfordvCrystal PalacePremier League · England | 0–0 | Premier League · England |
| 2022-02-09 | Man CityvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2022-01-22 | BrentfordvWolvesPremier League · England | 1–2 | Premier League · England |
| 2022-01-19 | BrentfordvMan UnitedPremier League · England | 1–3 | Premier League · England |
| 2022-01-16 | LiverpoolvBrentfordPremier League · England | 3–0 | Premier League · England |
| 2022-01-11 | SouthamptonvBrentfordPremier League · England | 4–1 | Premier League · England |
| 2022-01-02 | BrentfordvAston VillaPremier League · England | 2–1 | Premier League · England |