| 2021-12-29 | BrentfordvMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-12-26 | BrightonvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2021-12-10 | BrentfordvWatfordPremier League · England | 2–1 | Premier League · England |
| 2021-12-05 | LeedsvBrentfordPremier League · England | 2–2 | Premier League · England |
| 2021-12-02 | TottenhamvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2021-11-28 | BrentfordvEvertonPremier League · England | 1–0 | Premier League · England |
| 2021-11-20 | NewcastlevBrentfordPremier League · England | 3–3 | Premier League · England |
| 2021-11-06 | BrentfordvNorwichPremier League · England | 1–2 | Premier League · England |
| 2021-10-30 | BurnleyvBrentfordPremier League · England | 3–1 | Premier League · England |
| 2021-10-24 | BrentfordvLeicesterPremier League · England | 1–2 | Premier League · England |
| 2021-10-16 | BrentfordvChelseaPremier League · England | 0–1 | Premier League · England |
| 2021-10-03 | West HamvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2021-09-25 | BrentfordvLiverpoolPremier League · England | 3–3 | Premier League · England |
| 2021-09-18 | WolvesvBrentfordPremier League · England | 0–2 | Premier League · England |
| 2021-09-11 | BrentfordvBrightonPremier League · England | 0–1 | Premier League · England |
| 2021-08-28 | Aston VillavBrentfordPremier League · England | 1–1 | Premier League · England |
| 2021-08-21 | Crystal PalacevBrentfordPremier League · England | 0–0 | Premier League · England |
| 2021-08-13 | BrentfordvArsenalPremier League · England | 2–0 | Premier League · England |
| 2021-05-08 | Bristol CityvBrentfordChampionship · England | 1–3 | Championship · England |
| 2021-05-01 | BrentfordvWatfordChampionship · England | 2–0 | Championship · England |
| 2021-04-27 | BrentfordvRotherhamChampionship · England | 1–0 | Championship · England |
| 2021-04-24 | BournemouthvBrentfordChampionship · England | 0–1 | Championship · England |
| 2021-04-20 | BrentfordvCardiffChampionship · England | 1–1 | Championship · England |
| 2021-04-17 | BrentfordvMillwallChampionship · England | 0–0 | Championship · England |
| 2021-04-10 | PrestonvBrentfordChampionship · England | 0–5 | Championship · England |
| 2021-04-06 | BrentfordvBirminghamChampionship · England | 0–0 | Championship · England |
| 2021-04-03 | HuddersfieldvBrentfordChampionship · England | 1–1 | Championship · England |
| 2021-03-20 | BrentfordvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2021-03-16 | DerbyvBrentfordChampionship · England | 2–2 | Championship · England |
| 2021-03-12 | BlackburnvBrentfordChampionship · England | 0–1 | Championship · England |
| 2021-03-03 | NorwichvBrentfordChampionship · England | 1–0 | Championship · England |
| 2021-02-27 | BrentfordvStokeChampionship · England | 2–1 | Championship · England |
| 2021-02-24 | BrentfordvSheffield WedsChampionship · England | 3–0 | Championship · England |
| 2021-02-20 | CoventryvBrentfordChampionship · England | 2–0 | Championship · England |
| 2021-02-17 | QPRvBrentfordChampionship · England | 2–1 | Championship · England |
| 2021-02-14 | BrentfordvBarnsleyChampionship · England | 0–2 | Championship · England |
| 2021-02-10 | ReadingvBrentfordChampionship · England | 1–3 | Championship · England |
| 2021-02-06 | MiddlesbroughvBrentfordChampionship · England | 1–4 | Championship · England |
| 2021-02-03 | BrentfordvBristol CityChampionship · England | 3–2 | Championship · England |
| 2021-01-30 | BrentfordvWycombeChampionship · England | 7–2 | Championship · England |
| 2021-01-27 | SwanseavBrentfordChampionship · England | 1–1 | Championship · England |
| 2021-01-20 | BrentfordvLutonChampionship · England | 1–0 | Championship · England |