| 2021-12-26 | Aston VillavChelseaPremier League · England | 1–3 | Premier League · England |
| 2021-12-14 | NorwichvAston VillaPremier League · England | 0–2 | Premier League · England |
| 2021-12-11 | LiverpoolvAston VillaPremier League · England | 1–0 | Premier League · England |
| 2021-12-05 | Aston VillavLeicesterPremier League · England | 2–1 | Premier League · England |
| 2021-12-01 | Aston VillavMan CityPremier League · England | 1–2 | Premier League · England |
| 2021-11-27 | Crystal PalacevAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-11-20 | Aston VillavBrightonPremier League · England | 2–0 | Premier League · England |
| 2021-11-05 | SouthamptonvAston VillaPremier League · England | 1–0 | Premier League · England |
| 2021-10-31 | Aston VillavWest HamPremier League · England | 1–4 | Premier League · England |
| 2021-10-22 | ArsenalvAston VillaPremier League · England | 3–1 | Premier League · England |
| 2021-10-16 | Aston VillavWolvesPremier League · England | 2–3 | Premier League · England |
| 2021-10-03 | TottenhamvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2021-09-25 | Man UnitedvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-09-18 | Aston VillavEvertonPremier League · England | 3–0 | Premier League · England |
| 2021-09-11 | ChelseavAston VillaPremier League · England | 3–0 | Premier League · England |
| 2021-08-28 | Aston VillavBrentfordPremier League · England | 1–1 | Premier League · England |
| 2021-08-21 | Aston VillavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-08-14 | WatfordvAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-05-23 | Aston VillavChelseaPremier League · England | 2–1 | Premier League · England |
| 2021-05-19 | TottenhamvAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-05-16 | Crystal PalacevAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-05-13 | Aston VillavEvertonPremier League · England | 0–0 | Premier League · England |
| 2021-05-09 | Aston VillavMan UnitedPremier League · England | 1–3 | Premier League · England |
| 2021-05-01 | EvertonvAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-04-25 | Aston VillavWest BromPremier League · England | 2–2 | Premier League · England |
| 2021-04-21 | Aston VillavMan CityPremier League · England | 1–2 | Premier League · England |
| 2021-04-10 | LiverpoolvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2021-04-04 | Aston VillavFulhamPremier League · England | 3–1 | Premier League · England |
| 2021-03-21 | Aston VillavTottenhamPremier League · England | 0–2 | Premier League · England |
| 2021-03-12 | NewcastlevAston VillaPremier League · England | 1–1 | Premier League · England |
| 2021-03-06 | Aston VillavWolvesPremier League · England | 0–0 | Premier League · England |
| 2021-03-03 | Sheffield UnitedvAston VillaPremier League · England | 1–0 | Premier League · England |
| 2021-02-27 | LeedsvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-02-21 | Aston VillavLeicesterPremier League · England | 1–2 | Premier League · England |
| 2021-02-13 | BrightonvAston VillaPremier League · England | 0–0 | Premier League · England |
| 2021-02-06 | Aston VillavArsenalPremier League · England | 1–0 | Premier League · England |
| 2021-02-03 | Aston VillavWest HamPremier League · England | 1–3 | Premier League · England |
| 2021-01-30 | SouthamptonvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-01-27 | BurnleyvAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-01-23 | Aston VillavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-01-20 | Man CityvAston VillaPremier League · England | 2–0 | Premier League · England |
| 2021-01-01 | Man UnitedvAston VillaPremier League · England | 2–1 | Premier League · England |