| 2021-09-13 | GranadavBetisLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-09-13 | OrebrovVarbergAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2021-09-13 | FK RostovvKrasnodarPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-09-13 | LugovHuescaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2021-09-13 | AldosivivGodoy CruzLiga Profesional · Argentina | 1–4 | Liga Profesional · Argentina |
| 2021-09-13 | Le HavrevToulouseLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-09-13 | TondelavEstorilPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-09-13 | MjallbyvAIKAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-09-13 | FluminensevSao PauloSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-09-13 | Farul ConstantavAcademica ClinceniSuperliga · Romania | 5–0 | Superliga · Romania |
| 2021-09-13 | GaziantepvAntalyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-09-13 | QueretarovNecaxaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-09-13 | BolognavVeronaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-09-13 | Radomiak RadomvPogon SzczecinEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-09-13 | San LorenzovRacing ClubLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-09-13 | GetafevElcheLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-09-13 | Beerschot VAvSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-09-13 | OdensevSonderjyskeSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-09-13 | IndependientevLanusLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-09-13 | Rubin KazanvUralPremier League · Russia | 4–0 | Premier League · Russia |
| 2021-09-13 | ElfsborgvHackenAllsvenskan · Sweden | 4–2 | Allsvenskan · Sweden |
| 2021-09-13 | Los Angeles FCvReal Salt LakeMLS · United States | 3–2 | MLS · United States |
| 2021-09-13 | Sarmiento JuninvHuracanLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-09-13 | MaritimovAroucaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-09-13 | LecznavWisla PlockEkstraklasa · Poland | 3–2 | Ekstraklasa · Poland |
| 2021-09-13 | AlanyasporvGiresunsporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-09-13 | Univ. CraiovavSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-09-13 | ArisvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2021-09-13 | EvertonvBurnleyPremier League · England | 3–1 | Premier League · England |
| 2021-09-12 | Club AmericavMazatlan FCLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-09-12 | TrabzonsporvGalatasaraySüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-09-12 | PalmeirasvFlamengo RJSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2021-09-12 | EspanolvAth MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-09-12 | MilanvLazioSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-09-12 | BochumvHerthaBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-09-12 | SochivUfaPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-09-12 | MoreirensevFamalicaoPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-09-12 | PaderbornvSchalke 042. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-09-12 | FCSBvDin. BucurestiSuperliga · Romania | 6–0 | Superliga · Romania |
| 2021-09-12 | OviedovCartagenaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-09-12 | HeartsvHibernianPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-09-12 | UNAM PumasvGuadalajara ChivasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-09-12 | Sturm GrazvA. KlagenfurtBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-09-12 | New England RevolutionvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2021-09-12 | Piast GliwicevZaglebieEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-09-12 | KalmarvDegerforsAllsvenskan · Sweden | 4–1 | Allsvenskan · Sweden |
| 2021-09-12 | AarhusvVejleSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-09-12 | Gamba OsakavVegalta SendaiJ1 League · Japan | 2–3 | J1 League · Japan |
| 2021-09-12 | OsasunavValenciaLa Liga · Spain | 1–4 | La Liga · Spain |
| 2021-09-12 | SpeziavUdineseSerie A · Italy | 0–1 | Serie A · Italy |