| 2010-04-25 | CadizvGironaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-04-25 | MallorcavMalagaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-04-25 | HoffenheimvHamburgBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2010-04-25 | UdinesevSienaSerie A · Italy | 4–1 | Serie A · Italy |
| 2010-04-25 | GenoavLazioSerie A · Italy | 1–2 | Serie A · Italy |
| 2010-04-25 | Frankfurt FSVvAugsburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-04-25 | GaziantepsporvBuyuksehyrSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2010-04-25 | LeiriavSp LisbonPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-04-25 | RomavSampdoriaSerie A · Italy | 1–2 | Serie A · Italy |
| 2010-04-25 | CordobavLevanteLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-04-25 | HerculesvSalamancaLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2010-04-25 | HibernianvRangersPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-04-25 | NavalvSp BragaPrimeira Liga · Portugal | 0–4 | Primeira Liga · Portugal |
| 2010-04-25 | JuventusvBariSerie A · Italy | 3–0 | Serie A · Italy |
| 2010-04-25 | Dundee UnitedvCelticPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2010-04-25 | LensvValenciennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-04-25 | SantandervVillarrealLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-04-25 | MarseillevSt EtienneLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-04-25 | BolognavParmaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-04-25 | KasimpasavFenerbahceSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2010-04-25 | ChelseavStokePremier League · England | 7–0 | Premier League · England |
| 2010-04-25 | LeixoesvAcademicaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2010-04-25 | Ath MadridvTenerifeLa Liga · Spain | 3–1 | La Liga · Spain |
| 2010-04-25 | NacionalvPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-04-25 | FreiburgvWolfsburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2010-04-25 | BielefeldvFortuna Dusseldorf2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-04-25 | BurnleyvLiverpoolPremier League · England | 0–4 | Premier League · England |
| 2010-04-25 | AlmeriavEspanolLa Liga · Spain | 0–1 | La Liga · Spain |
| 2010-04-25 | RecreativovNumanciaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2010-04-25 | NapolivCagliariSerie A · Italy | 0–0 | Serie A · Italy |
| 2010-04-25 | EvertonvFulhamPremier League · England | 2–1 | Premier League · England |
| 2010-04-25 | ToulousevAuxerreLigue 1 · France | 0–3 | Ligue 1 · France |
| 2010-04-24 | Nott'm ForestvPlymouthChampionship · England | 3–0 | Championship · England |
| 2010-04-24 | MillwallvLeyton OrientLeague One · England | 2–1 | League One · England |
| 2010-04-24 | NancyvMontpellierLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-04-24 | Port ValevNotts CountyLeague Two · England | 2–1 | League Two · England |
| 2010-04-24 | HerefordvRochdaleLeague Two · England | 2–1 | League Two · England |
| 2010-04-24 | StockportvHuddersfieldLeague One · England | 0–6 | League One · England |
| 2010-04-24 | ZaragozavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-04-24 | HeartsvMotherwellPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2010-04-24 | HerthavSchalke 04Bundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-04-24 | AscolivPiacenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-04-24 | Sheffield UnitedvSwanseaChampionship · England | 2–0 | Championship · England |
| 2010-04-24 | Queen of SthvAirdrie UtdChampionship · Scotland | 2–2 | Championship · Scotland |
| 2010-04-24 | CheltenhamvAldershotLeague Two · England | 1–2 | League Two · England |
| 2010-04-24 | Le MansvLilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-04-24 | CowdenbeathvBrechinLeague One · Scotland | 4–0 | League One · Scotland |
| 2010-04-24 | WolvesvBlackburnPremier League · England | 1–1 | Premier League · England |
| 2010-04-24 | West HamvWiganPremier League · England | 3–2 | Premier League · England |
| 2010-04-24 | Eastbourne BoroughvOxfordNational League · England | 1–0 | National League · England |