| 2021-09-16 | Sporting Kansas CityvMinnesota UnitedMLS · United States | 4–0 | MLS · United States |
| 2021-09-16 | San Jose EarthquakesvReal Salt LakeMLS · United States | 3–4 | MLS · United States |
| 2021-09-16 | Orlando CityvCF MontrealMLS · United States | 2–4 | MLS · United States |
| 2021-09-16 | Los Angeles GalaxyvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2021-09-16 | Austin FCvLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2021-09-16 | DC UnitedvChicago FireMLS · United States | 3–0 | MLS · United States |
| 2021-09-16 | Atlanta UtdvFC CincinnatiMLS · United States | 4–0 | MLS · United States |
| 2021-09-15 | SwanseavMillwallChampionship · England | 0–0 | Championship · England |
| 2021-09-15 | Argentinos JrsvPatronatoLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-09-15 | Bristol CityvLutonChampionship · England | 1–1 | Championship · England |
| 2021-09-15 | Union de Santa FevEstudiantes L.P.Liga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2021-09-15 | StokevBarnsleyChampionship · England | 1–1 | Championship · England |
| 2021-09-15 | CoventryvCardiffChampionship · England | 1–0 | Championship · England |
| 2021-09-15 | New York CityvFC DallasMLS · United States | 3–3 | MLS · United States |
| 2021-09-15 | Toronto FCvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2021-09-15 | Columbus CrewvNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2021-09-15 | Boca JuniorsvDefensa y JusticiaLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-09-15 | BirminghamvFulhamChampionship · England | 1–4 | Championship · England |
| 2021-09-15 | Nott'm ForestvMiddlesbroughChampionship · England | 0–2 | Championship · England |
| 2021-09-15 | BanfieldvRosario CentralLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-09-14 | SolihullvTorquayNational League · England | 2–1 | National League · England |
| 2021-09-14 | KTPvSJKVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-09-14 | Newport CountyvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-09-14 | Gimnasia L.P.vVelez SarsfieldLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-09-14 | Dag and RedvWeymouthNational League · England | 4–2 | National League · England |
| 2021-09-14 | BournemouthvQPRChampionship · England | 2–1 | Championship · England |
| 2021-09-14 | GrimsbyvWrexhamNational League · England | 3–1 | National League · England |
| 2021-09-14 | MaidenheadvStockportNational League · England | 0–2 | National League · England |
| 2021-09-14 | Talleres CordobavPlatenseLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-09-14 | BlackpoolvHuddersfieldChampionship · England | 0–3 | Championship · England |
| 2021-09-14 | Airdrie UtdvAlloaLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-09-14 | Sport RecifevInternacionalSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-09-14 | Arsenal SarandivColon Santa FELiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-09-14 | West BromvDerbyChampionship · England | 0–0 | Championship · England |
| 2021-09-14 | ChesterfieldvBarnetNational League · England | 4–2 | National League · England |
| 2021-09-14 | BlackburnvHullChampionship · England | 2–0 | Championship · England |
| 2021-09-14 | Boreham WoodvHalifaxNational League · England | 2–2 | National League · England |
| 2021-09-14 | Sheffield UnitedvPrestonChampionship · England | 2–2 | Championship · England |
| 2021-09-14 | SuttonvHartlepoolLeague Two · England | 1–0 | League Two · England |
| 2021-09-14 | LincolnvRotherhamLeague One · England | 1–1 | League One · England |
| 2021-09-14 | ReadingvPeterboroChampionship · England | 3–1 | Championship · England |
| 2021-09-14 | EastleighvDover AthleticNational League · England | 4–1 | National League · England |
| 2021-09-14 | SouthendvAldershotNational League · England | 2–3 | National League · England |
| 2021-09-14 | PachucavTolucaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-09-14 | Central CordobavAtl. TucumanLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-09-14 | Notts CountyvWealdstoneNational League · England | 3–2 | National League · England |
| 2021-09-14 | IlvesvHIFKVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-09-14 | Sligo RoversvDundalkPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-09-14 | AjacciovParis FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-09-13 | Finn HarpsvBohemiansPremier Division · Ireland | 1–2 | Premier Division · Ireland |