| 2021-09-18 | MortonvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-09-18 | Wisla PlockvJagielloniaEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-09-18 | ColchestervCrawley TownLeague Two · England | 0–1 | League Two · England |
| 2021-09-18 | ToulousevGrenobleLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-09-18 | Ath MadridvAth BilbaoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-09-18 | YeovilvChesterfieldNational League · England | 0–2 | National League · England |
| 2021-09-18 | Bristol RvsvLeyton OrientLeague Two · England | 1–3 | League Two · England |
| 2021-09-18 | IntervBolognaSerie A · Italy | 6–1 | Serie A · Italy |
| 2021-09-18 | RegginavSpalSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-09-18 | PortsmouthvCambridgeLeague One · England | 1–2 | League One · England |
| 2021-09-18 | ClydevQueens ParkLeague One · Scotland | 2–2 | League One · Scotland |
| 2021-09-18 | MiddlesbroughvBlackpoolChampionship · England | 1–2 | Championship · England |
| 2021-09-18 | St. GilloisevWaregemPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-09-18 | Lechia GdanskvPiast GliwiceEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-09-18 | Chindia TargovistevFarul ConstantaSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-09-18 | IbizavOviedoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-09-18 | Sligo RoversvShamrock RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-09-18 | CarlislevScunthorpeLeague Two · England | 2–2 | League Two · England |
| 2021-09-18 | Urawa RedsvCerezo OsakaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-09-18 | Queen of SthvArbroathChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-09-18 | PeterborovBirminghamChampionship · England | 3–0 | Championship · England |
| 2021-09-18 | Pogon SzczecinvCracoviaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-09-18 | LensvLilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-09-18 | Man CityvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2021-09-18 | CardiffvBournemouthChampionship · England | 0–1 | Championship · England |
| 2021-09-17 | Lech PoznanvWislaEkstraklasa · Poland | 5–0 | Ekstraklasa · Poland |
| 2021-09-17 | Edinburgh CityvStirlingLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2021-09-17 | AalborgvOdenseSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-09-17 | AltayvGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-09-17 | Atl. San LuisvClub TijuanaLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2021-09-17 | FC VoluntarivMioveniSuperliga · Romania | 4–0 | Superliga · Romania |
| 2021-09-17 | ZaglebievTermalica B-B.Ekstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-09-17 | HerthavGreuther FurthBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-09-17 | SassuolovTorinoSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-09-17 | Cercle BruggevEupenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-09-17 | IonikosvArisSuper League · Greece | 1–0 | Super League · Greece |
| 2021-09-17 | Schalke 04vKarlsruhe2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-09-17 | FC Rapid BucurestivGaz Metan MediasSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-09-17 | NurnbergvHansa Rostock2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-09-17 | PortimonensevSanta ClaraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-09-17 | CeltavCadizLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-09-17 | ComovFrosinoneSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-09-17 | Yeni MalatyasporvKaragumrukSüper Lig · Turkey | 3–4 | Süper Lig · Turkey |
| 2021-09-17 | StrasbourgvMetzLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-09-17 | AlcorconvAlmeriaLa Liga 2 · Spain | 0–4 | La Liga 2 · Spain |
| 2021-09-17 | NewcastlevLeedsPremier League · England | 1–1 | Premier League · England |
| 2021-09-17 | BresciavCrotoneSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-09-17 | Sparta RotterdamvNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-09-16 | Portland TimbersvColorado RapidsMLS · United States | 2–2 | MLS · United States |
| 2021-09-16 | Newells Old BoysvRiver PlateLiga Profesional · Argentina | 1–4 | Liga Profesional · Argentina |