| 2021-09-18 | MainzvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-09-18 | ZaragozavSociedad BLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-09-18 | Velez SarsfieldvAldosiviLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2021-09-18 | Austria ViennavAltachBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-09-18 | BarnsleyvBlackburnChampionship · England | 0–0 | Championship · England |
| 2021-09-18 | NimesvAmiensLigue 2 · France | 3–3 | Ligue 2 · France |
| 2021-09-18 | BelenensesvGil VicentePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-09-18 | Chapecoense-SCvPalmeirasSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-09-18 | BurnleyvArsenalPremier League · England | 0–1 | Premier League · England |
| 2021-09-18 | SivassporvGaziantepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-09-18 | Werder BremenvHamburg2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-09-18 | Racing ClubvTalleres CordobaLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-09-18 | PrestonvWest BromChampionship · England | 1–1 | Championship · England |
| 2021-09-18 | Shonan BellmarevAvispa FukuokaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-09-18 | VicenzavPisaSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-09-18 | UtrechtvWaalwijkEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-09-18 | NecaxavAtlasLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2021-09-18 | FalkirkvDumbartonLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-09-18 | SandhausenvHeidenheim2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-09-18 | CowdenbeathvForfarLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-09-18 | HakavIlvesVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-09-18 | KasimpasavTrabzonsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-09-18 | Sagan TosuvOita TrinitaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-09-18 | Kashima AntlersvGamba OsakaJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-09-18 | BoltonvRotherhamLeague One · England | 0–2 | League One · England |
| 2021-09-18 | PartickvKilmarnockChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-09-18 | Inter MiamivNew York Red BullsMLS · United States | 0–4 | MLS · United States |
| 2021-09-18 | OldhamvHartlepoolLeague Two · England | 0–0 | League Two · England |
| 2021-09-18 | NancyvLe HavreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-09-18 | TorquayvSouthendNational League · England | 1–0 | National League · England |
| 2021-09-18 | LincolnvIpswichLeague One · England | 0–1 | League One · England |
| 2021-09-18 | WealdstonevAldershotNational League · England | 2–2 | National League · England |
| 2021-09-18 | HalifaxvStockportNational League · England | 3–0 | National League · England |
| 2021-09-18 | OddvLillestromEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2021-09-18 | NorwichvWatfordPremier League · England | 1–3 | Premier League · England |
| 2021-09-18 | RodezvAjaccioLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-09-18 | UfavKhimkiPremier League · Russia | 3–2 | Premier League · Russia |
| 2021-09-18 | Airdrie UtdvEast FifeLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-09-18 | Atletico-MGvSport RecifeSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-09-18 | SolihullvBoreham WoodNational League · England | 3–1 | National League · England |
| 2021-09-18 | Krylya SovetovvFK RostovPremier League · Russia | 4–2 | Premier League · Russia |
| 2021-09-18 | OostendevBeerschot VAPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-09-18 | Fleetwood TownvSunderlandLeague One · England | 2–2 | League One · England |
| 2021-09-18 | StevenagevForest GreenLeague Two · England | 0–4 | League Two · England |
| 2021-09-18 | Quevilly RouenvAuxerreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-09-18 | MonzavTernanaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-09-18 | Pau FCvValenciennesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-09-18 | LeccevAlessandriaSerie B · Italy | 3–2 | Serie B · Italy |
| 2021-09-18 | KristiansundvHaugesundEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-09-18 | AdmiravHartbergBundesliga · Austria | 1–1 | Bundesliga · Austria |