| 2010-05-04 | NimesvBrestLigue 2 · France | 1–0 | Ligue 2 · France |
| 2010-05-03 | GimnasticvReal UnionLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-05-03 | EmpolivBresciaSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-05-03 | WiganvHullPremier League · England | 2–2 | Premier League · England |
| 2010-05-03 | BlackburnvArsenalPremier League · England | 2–1 | Premier League · England |
| 2010-05-03 | MetzvAngersLigue 2 · France | 1–0 | Ligue 2 · France |
| 2010-05-02 | HeraclesvDen HaagEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2010-05-02 | OlhanensevLeixoesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2010-05-02 | GroningenvSpartaEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-05-02 | MontpelliervLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-05-02 | RennesvSochauxLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-05-02 | DuisburgvKarlsruhe2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-05-02 | St EtiennevLensLigue 1 · France | 1–4 | Ligue 1 · France |
| 2010-05-02 | ValenciennesvLorientLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-05-02 | Sheffield WedsvCrystal PalaceChampionship · England | 2–2 | Championship · England |
| 2010-05-02 | AhlenvFrankfurt FSV2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-05-02 | PlymouthvPeterboroChampionship · England | 1–2 | Championship · England |
| 2010-05-02 | NijmegenvAjaxEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2010-05-02 | AugsburgvMunich 18602. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2010-05-02 | SienavPalermoSerie A · Italy | 1–2 | Serie A · Italy |
| 2010-05-02 | PortovBenficaPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-05-02 | SevillavAth MadridLa Liga · Spain | 3–1 | La Liga · Spain |
| 2010-05-02 | UtrechtvVitesseEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-05-02 | SalamancavRecreativoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-05-02 | DenizlisporvGenclerbirligiSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2010-05-02 | SampdoriavLivornoSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-05-02 | QPRvNewcastleChampionship · England | 0–1 | Championship · England |
| 2010-05-02 | Sp LisbonvNavalPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2010-05-02 | Union BerlinvBielefeld2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2010-05-02 | Roda JCvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-05-02 | ReadingvPrestonChampionship · England | 4–1 | Championship · England |
| 2010-05-02 | LillevNancyLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-05-02 | PaderbornvAachen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-05-02 | Sp BragavPacos FerreiraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2010-05-02 | BelenensesvLeiriaPrimeira Liga · Portugal | 5–2 | Primeira Liga · Portugal |
| 2010-05-02 | LiverpoolvChelseaPremier League · England | 0–2 | Premier League · England |
| 2010-05-02 | CoventryvWatfordChampionship · England | 0–4 | Championship · England |
| 2010-05-02 | LeicestervMiddlesbroughChampionship · England | 2–0 | Championship · England |
| 2010-05-02 | AcademicavNacionalPrimeira Liga · Portugal | 3–3 | Primeira Liga · Portugal |
| 2010-05-02 | OberhausenvFortuna Dusseldorf2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-05-02 | LaziovInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2010-05-02 | SwanseavDoncasterChampionship · England | 0–0 | Championship · England |
| 2010-05-02 | BordeauxvToulouseLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-05-02 | BoulognevNiceLigue 1 · France | 3–3 | Ligue 1 · France |
| 2010-05-02 | DerbyvCardiffChampionship · England | 2–0 | Championship · England |
| 2010-05-02 | Rio AvevGuimaraesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2010-05-02 | Real MadridvOsasunaLa Liga · Spain | 3–2 | La Liga · Spain |
| 2010-05-02 | WaalwijkvVVV VenloEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2010-05-02 | BarivGenoaSerie A · Italy | 3–0 | Serie A · Italy |
| 2010-05-02 | ScunthorpevNott'm ForestChampionship · England | 2–2 | Championship · England |