| 2021-09-19 | MarseillevRennesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-09-19 | HuescavFuenlabradaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-09-19 | Real Salt LakevSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2021-09-19 | BahiavBragantinoSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-09-19 | KortrijkvGentPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-09-19 | Sturm GrazvTirolBundesliga · Austria | 5–0 | Bundesliga · Austria |
| 2021-09-19 | InternacionalvFortalezaSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-09-18 | GenoavFiorentinaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-09-18 | TokushimavKawasaki FrontaleJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-09-18 | MillwallvCoventryChampionship · England | 1–1 | Championship · England |
| 2021-09-18 | Holstein KielvHannover2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-09-18 | PeterheadvCove RangersLeague One · Scotland | 0–1 | League One · Scotland |
| 2021-09-18 | TranmerevSalfordLeague Two · England | 2–0 | League Two · England |
| 2021-09-18 | Godoy CruzvSarmiento JuninLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-09-18 | FC TokyovYokohama FCJ1 League · Japan | 4–0 | J1 League · Japan |
| 2021-09-18 | Radomiak RadomvSlask WroclawEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-09-18 | Vissel KobevHokkaido Consadole SapporoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-09-18 | MontrosevAlloaLeague One · Scotland | 0–2 | League One · Scotland |
| 2021-09-18 | Athletico-PRvJuventudeSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-09-18 | Aston VillavEvertonPremier League · England | 3–0 | Premier League · England |
| 2021-09-18 | WeymouthvDover AthleticNational League · England | 1–1 | National League · England |
| 2021-09-18 | Bayern MunichvBochumBundesliga · Germany | 7–0 | Bundesliga · Germany |
| 2021-09-18 | FamalicaovMaritimoPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-09-18 | VallecanovGetafeLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-09-18 | NorthamptonvSwindonLeague Two · England | 1–1 | League Two · England |
| 2021-09-18 | HeerenveenvFor SittardEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-09-18 | Fortuna DusseldorfvRegensburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-09-18 | HibernianvSt MirrenPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2021-09-18 | Kashiwa ReysolvSanfrecce HiroshimaJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-09-18 | AscolivBeneventoSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-09-18 | AberdeenvSt JohnstonePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-09-18 | ElchevLevanteLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-09-18 | MechelenvOud-Heverlee LeuvenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-09-18 | St EtiennevBordeauxLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-09-18 | Shimizu S-PulsevVegalta SendaiJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-09-18 | HullvSheffield UnitedChampionship · England | 1–3 | Championship · England |
| 2021-09-18 | HamiltonvAyrChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-09-18 | AccringtonvWiganLeague One · England | 1–4 | League One · England |
| 2021-09-18 | Albion RvsvKelty HeartsLeague Two · Scotland | 0–3 | League Two · Scotland |
| 2021-09-18 | ElginvAnnan AthleticLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2021-09-18 | BielefeldvHoffenheimBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-09-18 | CharleroivClub BruggePro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-09-18 | Notts CountyvMaidenheadNational League · England | 1–0 | National League · England |
| 2021-09-18 | LeganesvAmorebietaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-09-18 | CheltenhamvOxfordLeague One · England | 1–0 | League One · England |
| 2021-09-18 | HackenvMjallbyAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-09-18 | SochauxvParis FCLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-09-18 | BastiavCaenLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-09-18 | Willem IIvGroningenEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-09-18 | StranraervStenhousemuirLeague Two · Scotland | 2–0 | League Two · Scotland |