| 2021-12-15 | LegiavZaglebieEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2021-12-15 |  Indonesiav VietnamAFF Championship | 0–0 | AFF Championship |
| 2021-12-15 | MechelenvGentPro League · Belgium | 4–3 | Pro League · Belgium |
| 2021-12-15 | RangersvSt JohnstonePremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-12-15 | FCSBvFC Rapid BucurestiSuperliga · Romania | 3–1 | Superliga · Romania |
| 2021-12-15 | BrightonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-12-15 | M'gladbachvEin FrankfurtBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-12-15 |  Cambodiav LaosAFF Championship | 3–0 | AFF Championship |
| 2021-12-15 | CangzhouvShanghai ShenhuaSuper League · China | 1–1 | Super League · China |
| 2021-12-14 | HalmstadvHelsingborgAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2021-12-14 | Academica ClincenivFC VoluntariSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-12-14 | Radomiak RadomvPiast GliwiceEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-12-14 | HalifaxvKings LynnNational League · England | 2–0 | National League · England |
| 2021-12-14 | Cercle BruggevSeraingPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-14 |  Singaporev Timor-LesteAFF Championship | 2–0 | AFF Championship |
| 2021-12-14 | OostendevKortrijkPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-12-14 | WolfsburgvFC KolnBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-12-14 | StuttgartvBayern MunichBundesliga · Germany | 0–5 | Bundesliga · Germany |
| 2021-12-14 | NorwichvAston VillaPremier League · England | 0–2 | Premier League · England |
| 2021-12-14 | HibernianvDundeePremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-12-14 | Univ. CraiovavUTA AradSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-12-14 | AnderlechtvSt TruidenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-14 | Man CityvLeedsPremier League · England | 7–0 | Premier League · England |
| 2021-12-14 | BielefeldvBochumBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-12-14 | EastleighvSolihullNational League · England | 0–0 | National League · England |
| 2021-12-14 | Asteras TripolisvPanetolikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-12-14 | MainzvHerthaBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-12-14 |  Philippinesv ThailandAFF Championship | 1–2 | AFF Championship |
| 2021-12-13 | Guangzhou CityvChangchun YataiSuper League · China | 0–2 | Super League · China |
| 2021-12-13 | RomavSpeziaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-12-13 | Beijing GuoanvGuangzhou FCSuper League · China | 1–0 | Super League · China |
| 2021-12-13 | Din. BucurestivChindia TargovisteSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-12-13 | BanfieldvArsenal SarandiLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-12-13 | ShenzhenvShanghai PortSuper League · China | 1–3 | Super League · China |
| 2021-12-13 | AroucavVizelaPrimeira Liga · Portugal | 1–4 | Primeira Liga · Portugal |
| 2021-12-13 | Talleres CordobavIndependienteLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-12-13 | CadizvGranadaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-12-13 | MirandesvSociedad BLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-12-13 | SochivSpartak MoscowPremier League · Russia | 3–0 | Premier League · Russia |
| 2021-12-13 | SivassporvGalatasaraySüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-12-13 | Warta PoznanvSlask WroclawEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-12-13 | HebeivShandong TaishanSuper League · China | 0–5 | Super League · China |
| 2021-12-13 | GaziantepvFenerbahceSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-12-13 | AtlasvClub LeonLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-12-13 | ToulousevRodezLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-12-12 | Akhmat GroznyvKhimkiPremier League · Russia | 4–1 | Premier League · Russia |
| 2021-12-12 | RegginavAlessandriaSerie B · Italy | 0–4 | Serie B · Italy |
| 2021-12-12 | OsasunavBarcelonaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-12-12 | AntwerpvStandardPro League · Belgium | 2–3 | Pro League · Belgium |
| 2021-12-12 | StrasbourgvMarseilleLigue 1 · France | 0–2 | Ligue 1 · France |