| 2021-09-26 | UdinesevFiorentinaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-09-26 | JuventusvSampdoriaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-09-26 | St MirrenvAberdeenPremiership · Scotland | 3–2 | Premiership · Scotland |
| 2021-09-26 | PAOKvAEKSuper League · Greece | 2–0 | Super League · Greece |
| 2021-09-26 | HackenvHammarbyAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-09-26 | SassuolovSalernitanaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-09-26 | HeraclesvWaalwijkEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-09-26 | SK RapidvSturm GrazBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2021-09-26 | Bodo/GlimtvValerengaEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-09-26 | DresdenvWerder Bremen2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-09-26 | OostendevAnderlechtPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-09-26 | LuzernvLuganoSuper League · Switzerland | 2–3 | Super League · Switzerland |
| 2021-09-26 | Sport RecifevFortalezaSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-09-26 | HJKvInter TurkuVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-09-26 | NorrkopingvVarbergAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-09-26 | FreiburgvAugsburgBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-09-26 | GrasshoppersvSionSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-09-26 | Central CordobavRiver PlateLiga Profesional · Argentina | 1–3 | Liga Profesional · Argentina |
| 2021-09-26 | HannovervSandhausen2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-09-26 | LugovZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-09-26 | Sp GijonvMalagaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-09-26 | SandefjordvStabaekEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-09-26 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–0 | MLS · United States |
| 2021-09-26 | BrondbyvAalborgSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-09-26 | New York CityvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2021-09-26 | HartbergvAustria ViennaBundesliga · Austria | 3–4 | Bundesliga · Austria |
| 2021-09-26 | Nagoya GrampusvOita TrinitaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-09-26 | IndependientevGodoy CruzLiga Profesional · Argentina | 1–4 | Liga Profesional · Argentina |
| 2021-09-26 | BochumvStuttgartBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-09-26 | EmpolivBolognaSerie A · Italy | 4–2 | Serie A · Italy |
| 2021-09-26 | CharleroivMechelenPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-09-26 | BetisvGetafeLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-09-26 | Clermontv MonacoLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-09-26 | VallecanovCadizLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-09-26 | SouthamptonvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-09-26 | Vancouver WhitecapsvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2021-09-26 | MoldevVikingEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-09-26 | Dynamo MoscowvRubin KazanPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-09-26 | ArsenalvTottenhamPremier League · England | 3–1 | Premier League · England |
| 2021-09-26 | FK RostovvAkhmat GroznyPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-09-26 | Union de Santa FevPatronatoLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-09-26 | CelticvDundee UnitedPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-09-26 | BarcelonavLevanteLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-09-26 | Tigres UANLvUNAM PumasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-09-26 | PortimonensevVizelaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-09-26 | JuventudevSantosSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-09-25 | CosenzavCrotoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-09-25 | WaregemvKortrijkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-09-25 | Paris SGvMontpellierLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-09-25 | StenhousemuirvElginLeague Two · Scotland | 1–2 | League Two · Scotland |