| 2021-09-26 | LamiavPanetolikosSuper League · Greece | 2–2 | Super League · Greece |
| 2021-09-26 | HataysporvFenerbahceSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-09-26 | OstersundsvDjurgardenAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2021-09-26 | BordeauxvRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-09-26 | SJKvLahtiVeikkausliiga · Finland | 4–1 | Veikkausliiga · Finland |
| 2021-09-26 | RosenborgvMjondalenEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-09-26 | ParmavPisaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-09-26 | Asteras TripolisvOlympiakosSuper League · Greece | 0–2 | Super League · Greece |
| 2021-09-26 | Columbus CrewvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2021-09-26 | HamburgvNurnberg2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-09-26 | KuPSvHIFKVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-09-26 | Club AmericavGuadalajara ChivasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-09-26 | MariehamnvKTPVeikkausliiga · Finland | 4–2 | Veikkausliiga · Finland |
| 2021-09-26 | FluminensevBragantinoSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-09-26 | PanathinaikosvVolos NFCSuper League · Greece | 5–1 | Super League · Greece |
| 2021-09-26 | LASKvAdmiraBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-09-26 | Portland TimbersvReal Salt LakeMLS · United States | 6–1 | MLS · United States |
| 2021-09-26 | Santa ClaravSp BragaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-09-26 | HibernianvSt JohnstonePremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-09-26 | MjallbyvElfsborgAllsvenskan · Sweden | 4–0 | Allsvenskan · Sweden |
| 2021-09-26 | Kawasaki FrontalevShonan BellmareJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-09-26 | Chicago FirevNashville SCMLS · United States | 0–0 | MLS · United States |
| 2021-09-26 | MallorcavOsasunaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-09-26 | St. GilloisevAntwerpPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-09-26 | ReimsvNantesLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-09-26 | Minnesota UnitedvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2021-09-26 | BrannvKristiansundEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-09-26 | Athletico-PRvGremioSerie A · Brazil | 4–2 | Serie A · Brazil |
| 2021-09-26 | DC UnitedvFC CincinnatiMLS · United States | 4–2 | MLS · United States |
| 2021-09-26 | IlvesvHonkaVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-09-26 | MarseillevLensLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-09-26 | KrasnodarvSochiPremier League · Russia | 3–0 | Premier League · Russia |
| 2021-09-26 | VicenzavCremoneseSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-09-26 | AZ AlkmaarvGo Ahead EaglesEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-09-26 | ViborgvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-09-26 | BuyuksehyrvRizesporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-09-26 | Slask WroclawvWisla PlockEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-09-26 | VejlevSilkeborgSuperliga · Denmark | 2–4 | Superliga · Denmark |
| 2021-09-26 | MirandesvLeganesLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-09-26 | Gamba OsakavKashiwa ReysolJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-09-26 | Hokkaido Consadole SapporovSanfrecce HiroshimaJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-09-26 | AC OuluvHakaVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-09-26 | LaziovRomaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-09-26 | GalatasarayvGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-09-26 | SociedadvElcheLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-09-26 | GiresunsporvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-09-26 | WislavPogon SzczecinEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-09-26 | BrestvMetzLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-09-26 | HeerenveenvTwenteEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2021-09-26 | TernanavSpalSerie B · Italy | 1–0 | Serie B · Italy |