| 2016-09-21 | UCAM MurciavAlmeriaLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2016-09-21 | Cruz AzulvTolucaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2016-09-21 | BolognavSampdoriaSerie A · Italy | 2–0 | Serie A · Italy |
| 2016-09-21 | Werder BremenvMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2016-09-21 | BastiavNancyLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-09-21 | LuzernvSionSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2016-09-21 | Tianjin Jinmen TigervChangchun YataiSuper League · China | 4–0 | Super League · China |
| 2016-09-21 | GranadavAth BilbaoLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-09-21 | RB LeipzigvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-09-21 | FC VoluntarivU CraiovaSuperliga · Romania | 0–1 | Superliga · Romania |
| 2016-09-21 | AtalantavPalermoSerie A · Italy | 0–1 | Serie A · Italy |
| 2016-09-21 | PueblavVeracruzLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2016-09-21 | CeltavSp GijonLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-09-21 | PescaravTorinoSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-09-21 | HannovervKarlsruhe2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2016-09-21 | VPSvSJKVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2016-09-21 | KuPSvIlvesVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2016-09-21 | OstersundsvNorrkopingAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2016-09-21 | ChievovSassuoloSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-09-21 | Bayern MunichvHerthaBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2016-09-21 | ConcordiavFC BotosaniSuperliga · Romania | 0–2 | Superliga · Romania |
| 2016-09-21 | SociedadvLas PalmasLa Liga · Spain | 4–1 | La Liga · Spain |
| 2016-09-21 | Beijing GuoanvYanbianSuper League · China | 3–0 | Super League · China |
| 2016-09-21 | MetzvBordeauxLigue 1 · France | 0–3 | Ligue 1 · France |
| 2016-09-21 | Randers FCvFC CopenhagenSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2016-09-21 | UdinesevFiorentinaSerie A · Italy | 2–2 | Serie A · Italy |
| 2016-09-21 | MariehamnvInter TurkuVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2016-09-21 | HuescavElcheLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2016-09-21 | Schalke 04vFC KolnBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2016-09-21 | VaduzvYoung BoysSuper League · Switzerland | 0–0 | Super League · Switzerland |
| 2016-09-21 | Erzgebirge AuevBielefeld2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2016-09-21 | JuventusvCagliariSerie A · Italy | 4–0 | Serie A · Italy |
| 2016-09-21 | NecaxavClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2016-09-21 | KaiserslauternvDresden2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2016-09-21 | PS KemivLahtiVeikkausliiga · Finland | 2–4 | Veikkausliiga · Finland |
| 2016-09-21 | Nicev MonacoLigue 1 · France | 4–0 | Ligue 1 · France |
| 2016-09-21 | HJKvRovaniemiVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2016-09-20 | WolfsburgvDortmundBundesliga · Germany | 1–5 | Bundesliga · Germany |
| 2016-09-20 | SpalvVeronaSerie B · Italy | 1–3 | Serie B · Italy |
| 2016-09-20 | DundalkvShamrock RoversPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2016-09-20 | LillevToulouseLigue 1 · France | 1–2 | Ligue 1 · France |
| 2016-09-20 | America MGvInternacionalSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2016-09-20 | Paris SGvDijonLigue 1 · France | 3–0 | Ligue 1 · France |
| 2016-09-20 | ScunthorpevCharltonLeague One · England | 0–0 | League One · England |
| 2016-09-20 | AscolivVicenzaSerie B · Italy | 2–0 | Serie B · Italy |
| 2016-09-20 | NiortvAjaccio GFCOLigue 2 · France | 0–0 | Ligue 2 · France |
| 2016-09-20 | LensvOrleansLigue 2 · France | 4–2 | Ligue 2 · France |
| 2016-09-20 | AjacciovAuxerreLigue 2 · France | 2–0 | Ligue 2 · France |
| 2016-09-20 | TernanavBariSerie B · Italy | 0–0 | Serie B · Italy |
| 2016-09-20 | LavalvSochauxLigue 2 · France | 1–1 | Ligue 2 · France |