| 2021-09-27 | Gaz Metan MediasvSepsi Sf. GheorgheSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-09-27 | CeltavGranadaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-09-27 | DegerforsvAIKAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-09-27 | AtromitosvArisSuper League · Greece | 1–3 | Super League · Greece |
| 2021-09-27 | Austin FCvLos Angeles GalaxyMLS · United States | 2–0 | MLS · United States |
| 2021-09-27 | Crystal PalacevBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-09-27 | DundalkvBohemiansPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-09-27 | KasimpasavKonyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-09-27 | ApollonvIonikosSuper League · Greece | 0–0 | Super League · Greece |
| 2021-09-27 | Santos LagunavMonterreyLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-09-27 | TrabzonsporvAlanyasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-09-27 | HalmstadvSiriusAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-09-27 | Pari NNvCSKA MoscowPremier League · Russia | 0–2 | Premier League · Russia |
| 2021-09-27 | Pacos FerreiravBelenensesPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-09-27 | ToulousevCaenLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-09-27 | FuenlabradavCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-09-27 | BoavistavEstorilPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-09-27 | Sporting Kansas CityvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2021-09-27 | Boca JuniorsvColon Santa FELiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-09-27 | GianninavOFI CreteSuper League · Greece | 1–1 | Super League · Greece |
| 2021-09-27 | VeneziavTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-09-27 | UralvArsenal TulaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-09-27 | Univ. CraiovavDin. BucurestiSuperliga · Romania | 5–0 | Superliga · Romania |
| 2021-09-27 | Atletico GOvCuiabaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-09-27 | Argentinos JrsvRacing ClubLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-09-26 | America MGvFlamengo RJSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-09-26 | Termalica B-B.vGornik Z.Ekstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-09-26 | InternacionalvBahiaSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-09-26 | NordsjaellandvFC CopenhagenSuperliga · Denmark | 1–5 | Superliga · Denmark |
| 2021-09-26 | GenkvSeraingPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-09-26 | GentvCercle BruggePro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-09-26 | Raith RvsvPartickChampionship · Scotland | 3–2 | Championship · Scotland |
| 2021-09-26 | TroyesvAngersLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-09-26 | Sao PaulovAtletico-MGSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-09-26 | TolucavAtl. San LuisLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-09-26 | Farul ConstantavMioveniSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-09-26 | PerugiavAlessandriaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-09-26 | BaselvZurichSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-09-26 | UTA AradvCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-09-26 | New England RevolutionvOrlando CityMLS · United States | 2–1 | MLS · United States |
| 2021-09-26 | NapolivCagliariSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-09-26 | San LorenzovDefensa y JusticiaLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-09-26 | Cerezo OsakavKashima AntlersJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-09-26 | ValladolidvAlcorconLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-09-26 | MidtjyllandvRanders FCSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-09-26 | FC BotosanivU Craiova 1948Superliga · Romania | 1–1 | Superliga · Romania |
| 2021-09-26 | HaugesundvOddEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-09-26 | Colorado RapidsvToronto FCMLS · United States | 0–0 | MLS · United States |
| 2021-09-26 | OviedovGironaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-09-26 | Sparta RotterdamvCambuurEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |