| 2016-09-23 | PanduriivViitorul ConstantaSuperliga · Romania | 0–1 | Superliga · Romania |
| 2016-09-23 | Red StarvNiortLigue 2 · France | 0–1 | Ligue 2 · France |
| 2016-09-23 | BohemiansvLongfordPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2016-09-23 | BraunschweigvFortuna Dusseldorf2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2016-09-23 | DundalkvDerry CityPremier Division · Ireland | 3–1 | Premier Division · Ireland |
| 2016-09-23 | DortmundvFreiburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2016-09-22 | Targu MuresvAstraSuperliga · Romania | 0–2 | Superliga · Romania |
| 2016-09-22 | TenerifevMallorcaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-09-22 | FCSBvCFR ClujSuperliga · Romania | 1–2 | Superliga · Romania |
| 2016-09-22 | Gaz Metan MediasvPoli TimisoaraSuperliga · Romania | 1–1 | Superliga · Romania |
| 2016-09-22 | HammarbyvHackenAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2016-09-22 | LyngbyvBrondbySuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2016-09-22 | LuganovGrasshoppersSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2016-09-22 | SonderjyskevOdenseSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2016-09-22 | VallecanovGetafeLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2016-09-22 | MonterreyvSantos LagunaLiga MX · Mexico | 5–2 | Liga MX · Mexico |
| 2016-09-22 | La CorunavLeganesLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-09-22 | ValenciavAlavesLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-09-22 | UNAM PumasvAtlasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2016-09-22 | AalborgvViborgSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2016-09-22 | St PaulivMunich 18602. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2016-09-22 | Club TijuanavQueretaroLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2016-09-22 | OviedovReus DeportiuLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-09-22 | OsasunavEspanolLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-09-22 | Club LeonvChiapasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2016-09-22 | GoteborgvOrebroAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2016-09-22 | Malmo FFvElfsborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2016-09-22 | GironavMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-09-21 | LeverkusenvAugsburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2016-09-21 | EmpolivInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2016-09-21 | KalmarvFalkenbergsAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2016-09-21 | GenoavNapoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-09-21 | LyonvMontpellierLigue 1 · France | 5–1 | Ligue 1 · France |
| 2016-09-21 | LausannevBaselSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2016-09-21 | Wurzburger KickersvUnion Berlin2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2016-09-21 | LevantevSevilla BLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2016-09-21 | RomavCrotoneSerie A · Italy | 4–0 | Serie A · Italy |
| 2016-09-21 | HelsingborgvSundsvallAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2016-09-21 | Real MadridvVillarrealLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-09-21 | GuingampvLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-09-21 | BarcelonavAth MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-09-21 | RennesvMarseilleLigue 1 · France | 3–2 | Ligue 1 · France |
| 2016-09-21 | AarhusvMidtjyllandSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2016-09-21 | Guadalajara ChivasvTigres UANLLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2016-09-21 | AngersvCaenLigue 1 · France | 2–1 | Ligue 1 · France |
| 2016-09-21 | GeflevJonkopingsAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2016-09-21 | HorsensvNordsjaellandSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2016-09-21 | NantesvSt EtienneLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-09-21 | DjurgardenvAIKAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2016-09-21 | MonarcasvPachucaLiga MX · Mexico | 1–5 | Liga MX · Mexico |