| 2010-08-07 | LokerenvKortrijkPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-08-07 | AyrvBrechinLeague One · Scotland | 0–2 | League One · Scotland |
| 2010-08-07 | HeerenveenvPSV EindhovenEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2010-08-07 | WalsallvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2010-08-07 | Crystal PalacevLeicesterChampionship · England | 3–2 | Championship · England |
| 2010-08-07 | PeterborovBristol RvsLeague One · England | 3–0 | League One · England |
| 2010-08-07 | CarlislevBrentfordLeague One · England | 2–0 | League One · England |
| 2010-08-07 | Sheffield WedsvDag and RedLeague One · England | 2–0 | League One · England |
| 2010-08-07 | Annan AthleticvEast StirlingLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2010-08-07 | RotherhamvLincolnLeague Two · England | 2–1 | League Two · England |
| 2010-08-07 | SouthamptonvPlymouthLeague One · England | 0–1 | League One · England |
| 2010-08-07 | AccringtonvAldershotLeague Two · England | 0–0 | League Two · England |
| 2010-08-07 | Paris SGvSt EtienneLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-08-07 | PrestonvDoncasterChampionship · England | 0–2 | Championship · England |
| 2010-08-07 | GillinghamvCheltenhamLeague Two · England | 1–1 | League Two · England |
| 2010-08-07 | ElginvArbroathLeague Two · Scotland | 3–5 | League Two · Scotland |
| 2010-08-07 | HeraclesvWillem IIEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2010-08-07 | RochdalevHartlepoolLeague One · England | 0–0 | League One · England |
| 2010-08-07 | BuryvPort ValeLeague Two · England | 0–1 | League Two · England |
| 2010-08-07 | EupenvWesterloPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-08-07 | ChesterfieldvBarnetLeague Two · England | 2–1 | League Two · England |
| 2010-08-07 | MarseillevCaenLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-08-07 | RennesvLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-08-07 | TorquayvNorthamptonLeague Two · England | 3–0 | League Two · England |
| 2010-08-07 | FalkirkvDunfermlineChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-08-07 | MiddlesbroughvIpswichChampionship · England | 1–3 | Championship · England |
| 2010-08-07 | East FifevAirdrie UtdLeague One · Scotland | 3–3 | League One · Scotland |
| 2010-08-07 | WycombevMorecambeLeague Two · England | 2–0 | League Two · England |
| 2010-08-07 | CharltonvBournemouthLeague One · England | 1–0 | League One · England |
| 2010-08-07 | Bristol CityvMillwallChampionship · England | 0–3 | Championship · England |
| 2010-08-07 | DundeevQueen of SthChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-08-07 | Raith RvsvPartickChampionship · Scotland | 4–0 | Championship · Scotland |
| 2010-08-07 | MortonvStirlingChampionship · Scotland | 0–0 | Championship · Scotland |
| 2010-08-07 | ToulousevBrestLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-08-07 | Albion RvsvBerwickLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-08-07 | ForfarvDumbartonLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-08-07 | WaregemvMechelenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-08-07 | BurnleyvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2010-08-07 | StevenagevMacclesfieldLeague Two · England | 2–2 | League Two · England |
| 2010-08-07 | Club BruggevSt TruidenPro League · Belgium | 4–1 | Pro League · Belgium |
| 2010-08-07 | GraafschapvExcelsiorEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2010-08-07 | YeovilvLeyton OrientLeague One · England | 2–1 | League One · England |
| 2010-08-07 | ClydevStranraerLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-08-07 | TranmerevOldhamLeague One · England | 1–2 | League One · England |
| 2010-08-07 | AuxerrevLorientLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-08-07 | Lyonv MonacoLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-08-07 | HullvSwanseaChampionship · England | 2–0 | Championship · England |
| 2010-08-07 | NijmegenvVVV VenloEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-08-07 | SochauxvArlesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-08-07 | StenhousemuirvPeterheadLeague One · Scotland | 3–1 | League One · Scotland |