| 2008-08-16 | AlloavRaith RvsLeague One · Scotland | 1–1 | League One · Scotland |
| 2008-08-16 | MansfieldvKidderminsterNational League · England | 4–2 | National League · England |
| 2008-08-16 | WalsallvScunthorpeLeague One · England | 2–1 | League One · England |
| 2008-08-16 | Sheffield UnitedvQPRChampionship · England | 3–0 | Championship · England |
| 2008-08-16 | BrechinvPeterheadLeague One · Scotland | 2–2 | League One · Scotland |
| 2008-08-16 | Cercle BruggevAnderlechtPro League · Belgium | 0–3 | Pro League · Belgium |
| 2008-08-16 | StranraervStirlingLeague One · Scotland | 1–0 | League One · Scotland |
| 2008-08-16 | StevenagevWeymouthNational League · England | 1–1 | National League · England |
| 2008-08-16 | Port ValevAccringtonLeague Two · England | 0–2 | League Two · England |
| 2008-08-16 | WatfordvCharltonChampionship · England | 1–0 | Championship · England |
| 2008-08-16 | St MirrenvKilmarnockPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2008-08-16 | DoncastervCardiffChampionship · England | 1–1 | Championship · England |
| 2008-08-16 | ReadingvPlymouthChampionship · England | 2–0 | Championship · England |
| 2008-08-16 | MorecambevRotherhamLeague Two · England | 1–3 | League Two · England |
| 2008-08-16 | OxfordvEastbourne BoroughNational League · England | 6–3 | National League · England |
| 2008-08-16 | ToulousevLe HavreLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-08-16 | RoeselarevKortrijkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2008-08-16 | St EtiennevSochauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-08-16 | PeterborovLeyton OrientLeague One · England | 3–0 | League One · England |
| 2008-08-16 | Bristol CityvDerbyChampionship · England | 1–1 | Championship · England |
| 2008-08-16 | WolvesvSheffield WedsChampionship · England | 4–1 | Championship · England |
| 2008-08-16 | Forest GreenvCrawley TownNational League · England | 1–0 | National League · England |
| 2008-08-16 | HibernianvFalkirkPremiership · Scotland | 3–2 | Premiership · Scotland |
| 2008-08-16 | BurnleyvIpswichChampionship · England | 0–3 | Championship · England |
| 2008-08-16 | GraysvNorthwichNational League · England | 2–1 | National League · England |
| 2008-08-16 | StockportvLeicesterLeague One · England | 0–0 | League One · England |
| 2008-08-16 | HullvFulhamPremier League · England | 2–1 | Premier League · England |
| 2008-08-16 | NorwichvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2008-08-16 | ForfarvElginLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2008-08-16 | MillwallvSouthendLeague One · England | 1–1 | League One · England |
| 2008-08-16 | HerefordvYeovilLeague One · England | 1–2 | League One · England |
| 2008-08-16 | Airdrie UtdvDundeeChampionship · Scotland | 0–0 | Championship · Scotland |
| 2008-08-16 | SwanseavNott'm ForestChampionship · England | 3–1 | Championship · England |
| 2008-08-16 | CambridgevBarrowNational League · England | 2–1 | National League · England |
| 2008-08-16 | CaenvValenciennesLigue 1 · France | 3–1 | Ligue 1 · France |
| 2008-08-16 | AyrvArbroathLeague One · Scotland | 2–1 | League One · Scotland |
| 2008-08-16 | BielefeldvWerder BremenBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2008-08-16 | DendervStandardPro League · Belgium | 1–3 | Pro League · Belgium |
| 2008-08-16 | RangersvHeartsPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2008-08-16 | East FifevQueens ParkLeague One · Scotland | 1–2 | League One · Scotland |
| 2008-08-16 | ColchestervHuddersfieldLeague One · England | 0–0 | League One · England |
| 2008-08-16 | TranmerevHartlepoolLeague One · England | 1–0 | League One · England |
| 2008-08-16 | WaregemvLokerenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2008-08-16 | PrestonvCrystal PalaceChampionship · England | 2–0 | Championship · England |
| 2008-08-16 | MiddlesbroughvTottenhamPremier League · England | 2–1 | Premier League · England |
| 2008-08-16 | RochdalevBarnetLeague Two · England | 3–1 | League Two · England |
| 2008-08-16 | YorkvHistonNational League · England | 1–1 | National League · England |
| 2008-08-16 | CheltenhamvSwindonLeague One · England | 2–0 | League One · England |
| 2008-08-16 | MortonvLivingstonChampionship · Scotland | 1–2 | Championship · Scotland |
| 2008-08-16 | BarnsleyvCoventryChampionship · England | 1–2 | Championship · England |