| 2021-09-30 | QueretarovGuadalajara ChivasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-09-30 | HakavHIFKVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-09-30 | DC UnitedvMinnesota UnitedMLS · United States | 3–1 | MLS · United States |
| 2021-09-30 | Colorado RapidsvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2021-09-30 |  Egyptv LiberiaFriendly | 2–0 | Friendly |
| 2021-09-30 | Houston DynamovVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-09-30 | Los Angeles FCvPortland TimbersMLS · United States | 1–2 | MLS · United States |
| 2021-09-30 | FC DallasvSporting Kansas CityMLS · United States | 1–3 | MLS · United States |
| 2021-09-30 | Chicago FirevNew York CityMLS · United States | 2–0 | MLS · United States |
| 2021-09-30 | Nashville SCvOrlando CityMLS · United States | 2–2 | MLS · United States |
| 2021-09-29 | RakowvRadomiak RadomEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-09-29 | PachucavClub AmericaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-09-29 | BarnsleyvNott'm ForestChampionship · England | 1–3 | Championship · England |
| 2021-09-29 | FulhamvSwanseaChampionship · England | 3–1 | Championship · England |
| 2021-09-29 | PeterborovBournemouthChampionship · England | 0–0 | Championship · England |
| 2021-09-29 | DerbyvReadingChampionship · England | 1–0 | Championship · England |
| 2021-09-29 | Raith RvsvDunfermlineChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-09-29 | StabaekvStromsgodsetEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-09-29 | MillwallvBristol CityChampionship · England | 1–0 | Championship · England |
| 2021-09-29 | Kawasaki FrontalevVissel KobeJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-09-29 | Atl. San LuisvTigres UANLLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2021-09-29 | Mazatlan FCvJuarezLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-09-29 | AtlasvPueblaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-09-29 | LutonvCoventryChampionship · England | 5–0 | Championship · England |
| 2021-09-28 | HullvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2021-09-28 | CardiffvWest BromChampionship · England | 0–4 | Championship · England |
| 2021-09-28 | SunderlandvCheltenhamLeague One · England | 5–0 | League One · England |
| 2021-09-28 | CharltonvBoltonLeague One · England | 1–4 | League One · England |
| 2021-09-28 | Milton Keynes DonsvFleetwood TownLeague One · England | 3–3 | League One · England |
| 2021-09-28 | BurtonvPortsmouthLeague One · England | 2–1 | League One · England |
| 2021-09-28 | OxfordvAccringtonLeague One · England | 5–1 | League One · England |
| 2021-09-28 | IpswichvDoncasterLeague One · England | 6–0 | League One · England |
| 2021-09-28 | AltrinchamvKings LynnNational League · England | 4–1 | National League · England |
| 2021-09-28 | PrestonvStokeChampionship · England | 1–1 | Championship · England |
| 2021-09-28 | NecaxavClub TijuanaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-09-28 | CambridgevGillinghamLeague One · England | 0–2 | League One · England |
| 2021-09-28 | RotherhamvAFC WimbledonLeague One · England | 3–0 | League One · England |
| 2021-09-28 | MorecambevLincolnLeague One · England | 2–0 | League One · England |
| 2021-09-28 | Newells Old BoysvHuracanLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-09-28 | QPRvBirminghamChampionship · England | 2–0 | Championship · England |
| 2021-09-28 | BromleyvGrimsbyNational League · England | 3–1 | National League · England |
| 2021-09-28 | MiddlesbroughvSheffield UnitedChampionship · England | 2–0 | Championship · England |
| 2021-09-28 | WiganvSheffield WedsLeague One · England | 1–2 | League One · England |
| 2021-09-28 | HuddersfieldvBlackburnChampionship · England | 3–2 | Championship · England |
| 2021-09-28 | ShrewsburyvWycombeLeague One · England | 1–2 | League One · England |
| 2021-09-28 | PlymouthvCreweLeague One · England | 1–1 | League One · England |
| 2021-09-28 | WokingvChesterfieldNational League · England | 3–1 | National League · England |
| 2021-09-27 | Piast GliwicevCracoviaEkstraklasa · Poland | 2–4 | Ekstraklasa · Poland |
| 2021-09-27 | GoteborgvKalmarAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-09-27 | AarhusvSonderjyskeSuperliga · Denmark | 1–0 | Superliga · Denmark |