| 2021-10-02 | Le HavrevDijonLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-10-02 | Gornik Z.vWisla PlockEkstraklasa · Poland | 4–2 | Ekstraklasa · Poland |
| 2021-10-02 | PeterheadvDumbartonLeague One · Scotland | 5–0 | League One · Scotland |
| 2021-10-02 | CrewevCambridgeLeague One · England | 2–2 | League One · England |
| 2021-10-02 | NicevBrestLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-10-02 | BirminghamvNott'm ForestChampionship · England | 0–3 | Championship · England |
| 2021-10-02 | AjacciovQuevilly RouenLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-10-02 | AFC WimbledonvBurtonLeague One · England | 1–1 | League One · England |
| 2021-10-02 | Din. BucurestivUTA AradSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-10-02 | WolvesvNewcastlePremier League · England | 2–1 | Premier League · England |
| 2021-10-02 | LanusvCentral CordobaLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-02 | KayserisporvTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-10-02 | CracoviavStal MielecEkstraklasa · Poland | 3–3 | Ekstraklasa · Poland |
| 2021-10-02 | SochauxvNiortLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-10-02 | Club LeonvAtl. San LuisLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-10-01 | MechelenvStandardPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-10-01 | Edinburgh CityvCowdenbeathLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-10-01 | Piast GliwicevWislaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-10-01 | StokevWest BromChampionship · England | 1–0 | Championship · England |
| 2021-10-01 | Werder BremenvHeidenheim2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-10-01 | MiovenivFC ArgesSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-10-01 | AldosivivUnion de Santa FeLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-10-01 |  Maldivesv NepalSAFF Cup | 0–1 | SAFF Cup |
| 2021-10-01 | Shonan BellmarevYokohama F. MarinosJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-10-01 | MaritimovMoreirensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-10-01 | Ath BilbaovAlavesLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-10-01 | Chindia TargovistevFCSBSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-10-01 | LeccevMonzaSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-10-01 | PonferradinavValladolidLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-10-01 | FC KolnvGreuther FurthBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-10-01 | Erzgebirge AuevHamburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-01 | LensvReimsLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-01 | AntalyasporvAd. DemirsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-10-01 | KaragumrukvBuyuksehyrSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-10-01 | Finn HarpsvDundalkPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2021-10-01 | Shamrock RoversvDerry CityPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-10-01 | CagliarivVeneziaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-10-01 | GroningenvTwenteEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-01 |  Sri Lankav BangladeshSAFF Cup | 0–1 | SAFF Cup |
| 2021-10-01 | OdensevVejleSuperliga · Denmark | 6–0 | Superliga · Denmark |
| 2021-10-01 | DroghedavSt. PatricksPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-10-01 | ZaglebievJagielloniaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-10-01 | ElfsborgvGoteborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-10-01 | FamalicaovGuimaraesPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-09-30 | Real Salt LakevLos Angeles GalaxyMLS · United States | 2–1 | MLS · United States |
| 2021-09-30 | Atlanta UtdvInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2021-09-30 | New York Red BullsvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2021-09-30 | Toronto FCvFC CincinnatiMLS · United States | 3–2 | MLS · United States |
| 2021-09-30 | San Jose EarthquakesvSeattle SoundersMLS · United States | 1–3 | MLS · United States |
| 2021-09-30 | CF MontrealvNew England RevolutionMLS · United States | 1–4 | MLS · United States |