| 2021-12-17 | WislavTermalica B-B.Ekstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-12-17 | Bayern MunichvWolfsburgBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-12-17 | Holstein KielvSt Pauli2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-12-17 | EstorilvFamalicaoPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-12-17 | SalernitanavInterSerie A · Italy | 0–5 | Serie A · Italy |
| 2021-12-17 | LaziovGenoaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-12-17 | CeltavEspanolLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-12-17 | SeraingvKortrijkPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-12-17 | Wisla PlockvLechia GdanskEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-12-17 | GiresunsporvAltaySüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-12-17 | Santa ClaravGuimaraesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-12-17 | BarnsleyvWest BromChampionship · England | 0–0 | Championship · England |
| 2021-12-17 | Edinburgh CityvForfarLeague Two · Scotland | 0–4 | League Two · Scotland |
| 2021-12-17 | GironavBurgosLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-12-17 | Fortuna DusseldorfvSandhausen2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-12-16 | Guangzhou FCvHebeiSuper League · China | 1–1 | Super League · China |
| 2021-12-16 | Farul ConstantavCFR ClujSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-12-16 | Changchun YataivShenzhenSuper League · China | 1–1 | Super League · China |
| 2021-12-16 | Shandong TaishanvBeijing GuoanSuper League · China | 2–1 | Super League · China |
| 2021-12-16 | IonikosvAEKSuper League · Greece | 0–1 | Super League · Greece |
| 2021-12-16 | LiverpoolvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2021-12-16 | ChelseavEvertonPremier League · England | 1–1 | Premier League · England |
| 2021-12-16 | Chindia TargovistevU Craiova 1948Superliga · Romania | 0–3 | Superliga · Romania |
| 2021-12-16 | MiovenivDin. BucurestiSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-12-16 | AntwerpvEupenPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-12-16 | Shanghai PortvGuangzhou CitySuper League · China | 1–0 | Super League · China |
| 2021-12-16 | OFI CretevArisSuper League · Greece | 1–1 | Super League · Greece |
| 2021-12-16 | GenkvCharleroiPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-12-15 | GianninavPAOKSuper League · Greece | 0–4 | Super League · Greece |
| 2021-12-15 | ArsenalvWest HamPremier League · England | 2–0 | Premier League · England |
| 2021-12-15 | AugsburgvRB LeipzigBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-12-15 | Ross CountyvCelticPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-12-15 | Young BoysvBaselSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-12-15 | RakowvGornik Z.Ekstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-12-15 | Crystal PalacevSouthamptonPremier League · England | 2–2 | Premier League · England |
| 2021-12-15 |  Tunisiav EgyptArab Cup | 1–0 | Arab Cup |
| 2021-12-15 | Henan Songshan LongmenvTianjin Jinmen TigerSuper League · China | 1–1 | Super League · China |
| 2021-12-15 | Chongqing Liangjiang AthleticvDalian ProSuper League · China | 0–1 | Super League · China |
| 2021-12-15 | BrannvJervEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-12-15 | FC ArgesvSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-12-15 | Qingdao FCvWuhan FCSuper League · China | 2–5 | Super League · China |
| 2021-12-15 | Oud-Heverlee LeuvenvClub BruggePro League · Belgium | 1–4 | Pro League · Belgium |
| 2021-12-15 | LeverkusenvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-12-15 | Union BerlinvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-12-15 | WaregemvSt. GilloisePro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-12-15 | AtromitosvOlympiakosSuper League · Greece | 0–3 | Super League · Greece |
| 2021-12-15 | FC BotosanivGaz Metan MediasSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-12-15 | DortmundvGreuther FurthBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-12-15 | LamiavVolos NFCSuper League · Greece | 2–2 | Super League · Greece |
| 2021-12-15 |  Qatarv AlgeriaArab Cup | 1–2 | Arab Cup |